TY - JOUR

T1 - СУБОПТИМАЛЬНЫЙ ОТВЕТ НА КОНТРОЛИРУЕМУЮ ОВАРИАЛЬНУЮ СТИМУЛЯЦИЮ В ЦИКЛАХ ЭКО/ИКСИ

AU - Nguyen, C. T.

AU - Niauri, D. A.

AU - Dzhemlikhanova, L. Kh

AU - Kogan, I. Yu

AU - Krikheli, I. O.

AU - Mekina, I. D.

AU - Lesik, E. A.

AU - Komarova, E. M.

AU - Ishchuk, M. A.

AU - Gzgzyan, A. M.

N1 - 36. Нгуен К.Т., Ниаури Д.А., Джемлиханова Л.Х., Коган И.Ю., Крихели И.О., Мекина И.Д., Лесик Е.А., Комарова Е.М., Ищук М.А., Гзгзян А.М. Субоптимальный ответ на контролируемую овариальную стимуляцию в циклах ЭКО/ИКСИ // Журнал акушерства и женских болезней. – 2020. – Т. 69. – № 6. – С. 51–60. https://doi.org/10.17816/JOWD69651-60

PY - 2020

Y1 - 2020

N2 - Hypothesis/Aims of study. currently, the frequency of suboptimal response (4-9 retrieved oocytes) to controlled ovarian stimulation (cOs) in woman is quite high; however, its efficacy is poorly studied. The aim of this study was to evaluate the main characteristics of iVF / icsi programs in patients with a suboptimal response to cOs. Study design, materials and methods. We performed a retrospective study of 412 iVF / icsi cycles in women with a suboptimal response to cOs, including a comparative analysis of clinical and embryological parameters, ovarian reserve and the efficacy of iVF / icsi protocols. Results. clinical pregnancy rate in ovarian stimulation cycles with a suboptimal response to cOs was 27.9%. The efficacy of assisted reproductive technology (arT) programs in women with uterine fibroids was significantly lower than in patients without fibroids (19.1% vs. 30.5%, p = 0.03; Or = 0.54; 95% ci: 0.31-0.95). clinical pregnancy rate in patients with male factor infertility was significantly higher than in women with anovulation (37.1% vs. 20.9%, р = 0.005; Or = 2.24; 95% ci: 1.27-3.94) or tubal factor infertility (37.1% vs. 24.8%, р = 0.02; Or = 1.79; 95% ci: 1.09-2.94). There were significant correlations between the number of retrieved oocytes with serum anti-Müllerian hormone (aMh) concentration (r = 0.32, p < 0.001) and antral follicle count (aFc) (r = 0.38, p < 0.001). in addition, the need for follicle-stimulating hormone (Fsh) preparations during cOs correlated significantly with ovarian reserve parameters (aMh and aFc) (r = –0.45 and –0.44, both p < 0.001, respectively) and the age of patients (r = 0.47; p < 0.001). Conclusion. The clinical pregnancy rate in women with a suboptimal response to cOs was low. concomitant uterine fibroids represented an additional factor of negative influence on iVF / icsi outcomes in women with a suboptimal response to cOs. The male factor of infertility in patients with a suboptimal response did not reduce the efficacy of arT programs. Ovarian reserve parameters in women with a suboptimal response correlated with the need for Fsh preparations during cOs and the number of retrieved oocytes.

AB - Hypothesis/Aims of study. currently, the frequency of suboptimal response (4-9 retrieved oocytes) to controlled ovarian stimulation (cOs) in woman is quite high; however, its efficacy is poorly studied. The aim of this study was to evaluate the main characteristics of iVF / icsi programs in patients with a suboptimal response to cOs. Study design, materials and methods. We performed a retrospective study of 412 iVF / icsi cycles in women with a suboptimal response to cOs, including a comparative analysis of clinical and embryological parameters, ovarian reserve and the efficacy of iVF / icsi protocols. Results. clinical pregnancy rate in ovarian stimulation cycles with a suboptimal response to cOs was 27.9%. The efficacy of assisted reproductive technology (arT) programs in women with uterine fibroids was significantly lower than in patients without fibroids (19.1% vs. 30.5%, p = 0.03; Or = 0.54; 95% ci: 0.31-0.95). clinical pregnancy rate in patients with male factor infertility was significantly higher than in women with anovulation (37.1% vs. 20.9%, р = 0.005; Or = 2.24; 95% ci: 1.27-3.94) or tubal factor infertility (37.1% vs. 24.8%, р = 0.02; Or = 1.79; 95% ci: 1.09-2.94). There were significant correlations between the number of retrieved oocytes with serum anti-Müllerian hormone (aMh) concentration (r = 0.32, p < 0.001) and antral follicle count (aFc) (r = 0.38, p < 0.001). in addition, the need for follicle-stimulating hormone (Fsh) preparations during cOs correlated significantly with ovarian reserve parameters (aMh and aFc) (r = –0.45 and –0.44, both p < 0.001, respectively) and the age of patients (r = 0.47; p < 0.001). Conclusion. The clinical pregnancy rate in women with a suboptimal response to cOs was low. concomitant uterine fibroids represented an additional factor of negative influence on iVF / icsi outcomes in women with a suboptimal response to cOs. The male factor of infertility in patients with a suboptimal response did not reduce the efficacy of arT programs. Ovarian reserve parameters in women with a suboptimal response correlated with the need for Fsh preparations during cOs and the number of retrieved oocytes.

KW - Clinical pregnancy rate

KW - Controlled ovarian stimulation

KW - IVF / icsi

KW - Suboptimal response

UR - http://www.scopus.com/inward/record.url?scp=85101152378&partnerID=8YFLogxK

U2 - 10.17816/JOWD69651-60

DO - 10.17816/JOWD69651-60

M3 - статья

AN - SCOPUS:85101152378

VL - 69

SP - 61

EP - 70

JO - ЖУРНАЛ АКУШЕРСТВА И ЖЕНСКИХ БОЛЕЗНЕЙ

JF - ЖУРНАЛ АКУШЕРСТВА И ЖЕНСКИХ БОЛЕЗНЕЙ

SN - 1684-0461

IS - 6

ER -