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СУБОПТИМАЛЬНЫЙ ОТВЕТ НА КОНТРОЛИРУЕМУЮ ОВАРИАЛЬНУЮ СТИМУЛЯЦИЮ В ЦИКЛАХ ЭКО/ИКСИ. / Nguyen, C. T.; Niauri, D. A.; Dzhemlikhanova, L. Kh; Kogan, I. Yu; Krikheli, I. O.; Mekina, I. D.; Lesik, E. A.; Komarova, E. M.; Ishchuk, M. A.; Gzgzyan, A. M.

In: ЖУРНАЛ АКУШЕРСТВА И ЖЕНСКИХ БОЛЕЗНЕЙ, Vol. 69, No. 6, 2020, p. 61-70.

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Nguyen, C. T. ; Niauri, D. A. ; Dzhemlikhanova, L. Kh ; Kogan, I. Yu ; Krikheli, I. O. ; Mekina, I. D. ; Lesik, E. A. ; Komarova, E. M. ; Ishchuk, M. A. ; Gzgzyan, A. M. / СУБОПТИМАЛЬНЫЙ ОТВЕТ НА КОНТРОЛИРУЕМУЮ ОВАРИАЛЬНУЮ СТИМУЛЯЦИЮ В ЦИКЛАХ ЭКО/ИКСИ. In: ЖУРНАЛ АКУШЕРСТВА И ЖЕНСКИХ БОЛЕЗНЕЙ. 2020 ; Vol. 69, No. 6. pp. 61-70.

BibTeX

@article{1f1a2c0fbfec4fbd87e8594f16fcdbd8,
title = "СУБОПТИМАЛЬНЫЙ ОТВЕТ НА КОНТРОЛИРУЕМУЮ ОВАРИАЛЬНУЮ СТИМУЛЯЦИЮ В ЦИКЛАХ ЭКО/ИКСИ",
abstract = "Hypothesis/Aims of study. currently, the frequency of suboptimal response (4-9 retrieved oocytes) to controlled ovarian stimulation (cOs) in woman is quite high; however, its efficacy is poorly studied. The aim of this study was to evaluate the main characteristics of iVF / icsi programs in patients with a suboptimal response to cOs. Study design, materials and methods. We performed a retrospective study of 412 iVF / icsi cycles in women with a suboptimal response to cOs, including a comparative analysis of clinical and embryological parameters, ovarian reserve and the efficacy of iVF / icsi protocols. Results. clinical pregnancy rate in ovarian stimulation cycles with a suboptimal response to cOs was 27.9%. The efficacy of assisted reproductive technology (arT) programs in women with uterine fibroids was significantly lower than in patients without fibroids (19.1% vs. 30.5%, p = 0.03; Or = 0.54; 95% ci: 0.31-0.95). clinical pregnancy rate in patients with male factor infertility was significantly higher than in women with anovulation (37.1% vs. 20.9%, р = 0.005; Or = 2.24; 95% ci: 1.27-3.94) or tubal factor infertility (37.1% vs. 24.8%, р = 0.02; Or = 1.79; 95% ci: 1.09-2.94). There were significant correlations between the number of retrieved oocytes with serum anti-M{\"u}llerian hormone (aMh) concentration (r = 0.32, p < 0.001) and antral follicle count (aFc) (r = 0.38, p < 0.001). in addition, the need for follicle-stimulating hormone (Fsh) preparations during cOs correlated significantly with ovarian reserve parameters (aMh and aFc) (r = –0.45 and –0.44, both p < 0.001, respectively) and the age of patients (r = 0.47; p < 0.001). Conclusion. The clinical pregnancy rate in women with a suboptimal response to cOs was low. concomitant uterine fibroids represented an additional factor of negative influence on iVF / icsi outcomes in women with a suboptimal response to cOs. The male factor of infertility in patients with a suboptimal response did not reduce the efficacy of arT programs. Ovarian reserve parameters in women with a suboptimal response correlated with the need for Fsh preparations during cOs and the number of retrieved oocytes.",
keywords = "Clinical pregnancy rate, Controlled ovarian stimulation, IVF / icsi, Suboptimal response",
author = "Nguyen, {C. T.} and Niauri, {D. A.} and Dzhemlikhanova, {L. Kh} and Kogan, {I. Yu} and Krikheli, {I. O.} and Mekina, {I. D.} and Lesik, {E. A.} and Komarova, {E. M.} and Ishchuk, {M. A.} and Gzgzyan, {A. M.}",
note = "36. Нгуен К.Т., Ниаури Д.А., Джемлиханова Л.Х., Коган И.Ю., Крихели И.О., Мекина И.Д., Лесик Е.А., Комарова Е.М., Ищук М.А., Гзгзян А.М. Субоптимальный ответ на контролируемую овариальную стимуляцию в циклах ЭКО/ИКСИ // Журнал акушерства и женских болезней. – 2020. – Т. 69. – № 6. – С. 51–60. https://doi.org/10.17816/JOWD69651-60",
year = "2020",
doi = "10.17816/JOWD69651-60",
language = "русский",
volume = "69",
pages = "61--70",
journal = "ЖУРНАЛ АКУШЕРСТВА И ЖЕНСКИХ БОЛЕЗНЕЙ",
issn = "1684-0461",
publisher = "Эко-Вектор",
number = "6",

}

RIS

TY - JOUR

T1 - СУБОПТИМАЛЬНЫЙ ОТВЕТ НА КОНТРОЛИРУЕМУЮ ОВАРИАЛЬНУЮ СТИМУЛЯЦИЮ В ЦИКЛАХ ЭКО/ИКСИ

AU - Nguyen, C. T.

AU - Niauri, D. A.

AU - Dzhemlikhanova, L. Kh

AU - Kogan, I. Yu

AU - Krikheli, I. O.

AU - Mekina, I. D.

AU - Lesik, E. A.

AU - Komarova, E. M.

AU - Ishchuk, M. A.

AU - Gzgzyan, A. M.

N1 - 36. Нгуен К.Т., Ниаури Д.А., Джемлиханова Л.Х., Коган И.Ю., Крихели И.О., Мекина И.Д., Лесик Е.А., Комарова Е.М., Ищук М.А., Гзгзян А.М. Субоптимальный ответ на контролируемую овариальную стимуляцию в циклах ЭКО/ИКСИ // Журнал акушерства и женских болезней. – 2020. – Т. 69. – № 6. – С. 51–60. https://doi.org/10.17816/JOWD69651-60

PY - 2020

Y1 - 2020

N2 - Hypothesis/Aims of study. currently, the frequency of suboptimal response (4-9 retrieved oocytes) to controlled ovarian stimulation (cOs) in woman is quite high; however, its efficacy is poorly studied. The aim of this study was to evaluate the main characteristics of iVF / icsi programs in patients with a suboptimal response to cOs. Study design, materials and methods. We performed a retrospective study of 412 iVF / icsi cycles in women with a suboptimal response to cOs, including a comparative analysis of clinical and embryological parameters, ovarian reserve and the efficacy of iVF / icsi protocols. Results. clinical pregnancy rate in ovarian stimulation cycles with a suboptimal response to cOs was 27.9%. The efficacy of assisted reproductive technology (arT) programs in women with uterine fibroids was significantly lower than in patients without fibroids (19.1% vs. 30.5%, p = 0.03; Or = 0.54; 95% ci: 0.31-0.95). clinical pregnancy rate in patients with male factor infertility was significantly higher than in women with anovulation (37.1% vs. 20.9%, р = 0.005; Or = 2.24; 95% ci: 1.27-3.94) or tubal factor infertility (37.1% vs. 24.8%, р = 0.02; Or = 1.79; 95% ci: 1.09-2.94). There were significant correlations between the number of retrieved oocytes with serum anti-Müllerian hormone (aMh) concentration (r = 0.32, p < 0.001) and antral follicle count (aFc) (r = 0.38, p < 0.001). in addition, the need for follicle-stimulating hormone (Fsh) preparations during cOs correlated significantly with ovarian reserve parameters (aMh and aFc) (r = –0.45 and –0.44, both p < 0.001, respectively) and the age of patients (r = 0.47; p < 0.001). Conclusion. The clinical pregnancy rate in women with a suboptimal response to cOs was low. concomitant uterine fibroids represented an additional factor of negative influence on iVF / icsi outcomes in women with a suboptimal response to cOs. The male factor of infertility in patients with a suboptimal response did not reduce the efficacy of arT programs. Ovarian reserve parameters in women with a suboptimal response correlated with the need for Fsh preparations during cOs and the number of retrieved oocytes.

AB - Hypothesis/Aims of study. currently, the frequency of suboptimal response (4-9 retrieved oocytes) to controlled ovarian stimulation (cOs) in woman is quite high; however, its efficacy is poorly studied. The aim of this study was to evaluate the main characteristics of iVF / icsi programs in patients with a suboptimal response to cOs. Study design, materials and methods. We performed a retrospective study of 412 iVF / icsi cycles in women with a suboptimal response to cOs, including a comparative analysis of clinical and embryological parameters, ovarian reserve and the efficacy of iVF / icsi protocols. Results. clinical pregnancy rate in ovarian stimulation cycles with a suboptimal response to cOs was 27.9%. The efficacy of assisted reproductive technology (arT) programs in women with uterine fibroids was significantly lower than in patients without fibroids (19.1% vs. 30.5%, p = 0.03; Or = 0.54; 95% ci: 0.31-0.95). clinical pregnancy rate in patients with male factor infertility was significantly higher than in women with anovulation (37.1% vs. 20.9%, р = 0.005; Or = 2.24; 95% ci: 1.27-3.94) or tubal factor infertility (37.1% vs. 24.8%, р = 0.02; Or = 1.79; 95% ci: 1.09-2.94). There were significant correlations between the number of retrieved oocytes with serum anti-Müllerian hormone (aMh) concentration (r = 0.32, p < 0.001) and antral follicle count (aFc) (r = 0.38, p < 0.001). in addition, the need for follicle-stimulating hormone (Fsh) preparations during cOs correlated significantly with ovarian reserve parameters (aMh and aFc) (r = –0.45 and –0.44, both p < 0.001, respectively) and the age of patients (r = 0.47; p < 0.001). Conclusion. The clinical pregnancy rate in women with a suboptimal response to cOs was low. concomitant uterine fibroids represented an additional factor of negative influence on iVF / icsi outcomes in women with a suboptimal response to cOs. The male factor of infertility in patients with a suboptimal response did not reduce the efficacy of arT programs. Ovarian reserve parameters in women with a suboptimal response correlated with the need for Fsh preparations during cOs and the number of retrieved oocytes.

KW - Clinical pregnancy rate

KW - Controlled ovarian stimulation

KW - IVF / icsi

KW - Suboptimal response

UR - http://www.scopus.com/inward/record.url?scp=85101152378&partnerID=8YFLogxK

U2 - 10.17816/JOWD69651-60

DO - 10.17816/JOWD69651-60

M3 - статья

AN - SCOPUS:85101152378

VL - 69

SP - 61

EP - 70

JO - ЖУРНАЛ АКУШЕРСТВА И ЖЕНСКИХ БОЛЕЗНЕЙ

JF - ЖУРНАЛ АКУШЕРСТВА И ЖЕНСКИХ БОЛЕЗНЕЙ

SN - 1684-0461

IS - 6

ER -

ID: 74990127