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Толерантность и минимизация иммуносупрессивной терапии после трансплантации печени. / Gerasimova, Olga A.; Borovik, V. V.; Marchenko, N. V.; Tileubergenov, I. I.

In: Vestnik Transplantologii i Iskusstvennykh Organov, Vol. 23, No. 3, 16.09.2021, p. 162-170.

Research output: Contribution to journal › Review article › peer-review

Harvard

Gerasimova, OA, Borovik, VV, Marchenko, NV & Tileubergenov, II 2021, 'Толерантность и минимизация иммуносупрессивной терапии после трансплантации печени', Vestnik Transplantologii i Iskusstvennykh Organov, vol. 23, no. 3, pp. 162-170. https://doi.org/10.15825/1995-1191-2021-3-162-170

APA

Gerasimova, O. A., Borovik, V. V., Marchenko, N. V., & Tileubergenov, I. I. (2021). Толерантность и минимизация иммуносупрессивной терапии после трансплантации печени. Vestnik Transplantologii i Iskusstvennykh Organov, 23(3), 162-170. https://doi.org/10.15825/1995-1191-2021-3-162-170

Vancouver

Gerasimova OA, Borovik VV, Marchenko NV, Tileubergenov II. Толерантность и минимизация иммуносупрессивной терапии после трансплантации печени. Vestnik Transplantologii i Iskusstvennykh Organov. 2021 Sep 16;23(3):162-170. https://doi.org/10.15825/1995-1191-2021-3-162-170

Author

Gerasimova, Olga A. ; Borovik, V. V. ; Marchenko, N. V. ; Tileubergenov, I. I. / Толерантность и минимизация иммуносупрессивной терапии после трансплантации печени. In: Vestnik Transplantologii i Iskusstvennykh Organov. 2021 ; Vol. 23, No. 3. pp. 162-170.

BibTeX

@article{90641f6d0bf34fdd87650c3aef76d643,
title = "Толерантность и минимизация иммуносупрессивной терапии после трансплантации печени",
abstract = "In this review of current publications, we look at the molecular mechanisms of tolerance of the liver and its allografts in terms of minimization and possibilities of withdrawing immunosuppressive therapy, mainly in the long-term period after liver transplantation. Information about clinical trials with regulatory T cells (Tregs) for the purpose of tolerance induction is presented. Data from a new consensus study on individualization of immunosuppressive therapy regimens are presented. Options for possible withdrawal of immunosuppression both in the early and in the long term after liver transplantation (LT) are considered. We suggest a way to study the lymphoproliferative potential of a liver transplant recipient to be investigated, since not only rejection determines life expectancy, but also the degree of immunosuppression effect on bone marrow depending on patient age.",
keywords = "Apoptosis, Immune tolerance, Immunosuppression, Liver transplant, Mesenchymal stem cells, NK cells, Regulatory T cells, APOPTOSIS, NK cells, RAPAMYCIN, REGULATORY T-CELLS, SURVIVAL, WITHDRAWAL, apoptosis, immune tolerance, immunosuppression, liver transplant, mesenchymal stem cells, regulatory T cells, Regulatory T cells, Immunosuppression, Immune tolerance, Liver transplant, Apoptosis, Mesenchymal stem cells",
author = "Gerasimova, {Olga A.} and Borovik, {V. V.} and Marchenko, {N. V.} and Tileubergenov, {I. I.}",
note = "Publisher Copyright: {\textcopyright} 2021 Russian Transplant Society. All rights reserved.",
year = "2021",
month = sep,
day = "16",
doi = "10.15825/1995-1191-2021-3-162-170",
language = "русский",
volume = "23",
pages = "162--170",
journal = "ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ",
issn = "1995-1191",
publisher = "Russian Transplant Society",
number = "3",

}

RIS

TY - JOUR

T1 - Толерантность и минимизация иммуносупрессивной терапии после трансплантации печени

AU - Gerasimova, Olga A.

AU - Borovik, V. V.

AU - Marchenko, N. V.

AU - Tileubergenov, I. I.

N1 - Publisher Copyright: © 2021 Russian Transplant Society. All rights reserved.

PY - 2021/9/16

Y1 - 2021/9/16

N2 - In this review of current publications, we look at the molecular mechanisms of tolerance of the liver and its allografts in terms of minimization and possibilities of withdrawing immunosuppressive therapy, mainly in the long-term period after liver transplantation. Information about clinical trials with regulatory T cells (Tregs) for the purpose of tolerance induction is presented. Data from a new consensus study on individualization of immunosuppressive therapy regimens are presented. Options for possible withdrawal of immunosuppression both in the early and in the long term after liver transplantation (LT) are considered. We suggest a way to study the lymphoproliferative potential of a liver transplant recipient to be investigated, since not only rejection determines life expectancy, but also the degree of immunosuppression effect on bone marrow depending on patient age.

AB - In this review of current publications, we look at the molecular mechanisms of tolerance of the liver and its allografts in terms of minimization and possibilities of withdrawing immunosuppressive therapy, mainly in the long-term period after liver transplantation. Information about clinical trials with regulatory T cells (Tregs) for the purpose of tolerance induction is presented. Data from a new consensus study on individualization of immunosuppressive therapy regimens are presented. Options for possible withdrawal of immunosuppression both in the early and in the long term after liver transplantation (LT) are considered. We suggest a way to study the lymphoproliferative potential of a liver transplant recipient to be investigated, since not only rejection determines life expectancy, but also the degree of immunosuppression effect on bone marrow depending on patient age.

KW - Apoptosis

KW - Immune tolerance

KW - Immunosuppression

KW - Liver transplant

KW - Mesenchymal stem cells

KW - NK cells

KW - Regulatory T cells

KW - APOPTOSIS

KW - NK cells

KW - RAPAMYCIN

KW - REGULATORY T-CELLS

KW - SURVIVAL

KW - WITHDRAWAL

KW - apoptosis

KW - immune tolerance

KW - immunosuppression

KW - liver transplant

KW - mesenchymal stem cells

KW - regulatory T cells

KW - Regulatory T cells

KW - Immunosuppression

KW - Immune tolerance

KW - Liver transplant

KW - Apoptosis

KW - Mesenchymal stem cells

UR - http://www.scopus.com/inward/record.url?scp=85116705001&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/2a2ded83-64b2-3dfc-8cb1-b968be9630f3/

U2 - 10.15825/1995-1191-2021-3-162-170

DO - 10.15825/1995-1191-2021-3-162-170

M3 - Обзорная статья

AN - SCOPUS:85116705001

VL - 23

SP - 162

EP - 170

JO - ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ

JF - ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ

SN - 1995-1191

IS - 3

ER -

ID: 90454921