In the article, I consider seven metaphysical postulates that lie in the foundations of modern physics. These are postulates: about the nature of space-time, about the existence, about the direction of time, about the causality, about the elementary event, about the nature of information and about the immutability of laws. The directions of critical analysis and possible radical revision of these postulates are briefly presented. It is supposed that this revision can indirectly contribute to the development of a theory that will be able to generalize quantum phenomena, gravity and the evolution of the universe.