Traumatic brain injury in some cases is a factor contributed to the destruction of the anatomical barrier between the ORL (oto-rhino-laryngeal) organs and intracranial space. To date, the relationship between traumatic brain injury, accompanied by damage to the ORL organs and inflammatory diseases of the brain, has been poorly studied. The purpose of this study was to assess the effect of traumatic brain injury on the incidence of pyo-inflammatory diseases of the brain in patients with ORL infections. Materials and methods. A retrospective analysis of cases of adult patients with otogenic and sinusogenic pyo-inflammatory brain diseases who received treatment from 1997 to 2017 was carried out. Results. Most often, ORL-associated pyo-inflammatory intracranial complications had an otogenic etiology accounting for 58.1% of cases among all patients and 6.8% among patients with a traumatic brain injury anamnesis. The second most frequent complication had sinusogenic etiology (33.4% and 3.2% of cases, respectively),