The authors made an analysis of short-term results of surgical treatment of the patients with gastrointestinal stromal tumors. MATERIALS AND METHODS. The data of medical histories of 94 patients were analyzed. The traditional, laparoscopic and endoscopic interventions were performed on the patients in order to remove the stromal tumors of the stomach and small intestine using radical methods. RESULTS. All surgeries (100 % of patients) were carried out in an adequate volume. There wasn’t noted the postoperative mortality and statistical difference of length of hospital stay (13,1 bed days after laparotomy and 11,5 bed days after minimally invasive interventions). The rate of early postoperative complications was higher after endoscopic interventions. CONCLUSIONS. Minimally invasive methods as well as traditional interventions are radical methods of treatment of gastrointestinal stromal tumors. An application of diverse and non-standardized approaches requires both the development of interdisciplinary collaboration and creation of optimal algorithm for choice of specific surgical technique based on localization, size and type of tumor growth in order to improve safety and reliability of treatment.