Introduction. Along with the increasing incidence of cholelithiasis, despite the success of its surgical treatment, there is a significant increase in the number of patients with the so-called postcholecystectomy syndrome (PCES). It is caused by the fact that cholecystectomy disturbs the process of bile secretion and does not compensate complex pathophysiological disorders occurring at cholelithiasis. The arsenal of effective means of medication and non-medication correction is relatively small that makes clinicians look for new methods of PCES therapy. Earlier studies have shown rather high clinical effectiveness of osteopathic correction in the complex treatment of patients with gastroenterological profile, which allows us to assume that osteopathic correction can be effective in the treatment of patients with PCES. The aim of the study: to substantiate the possibility of using osteopathic correction to eliminate the manifestations of postcholecystectomy syndrome. Materials and methods. The prospective controlled randomised study was conducted from January to July 2023 on the basis of the surgical department of the Kirishi Clinical Interdistrict Hospital of the Leningrad Region. Twenty-two patients aged 35 to 65 years were examined. All patients underwent surgical treatment of cholelithiasis and subsequently developed postcholecystectomy syndrome. According to the exclusion criteria, 2 patients dropped out of the study. Depending on the conducted treatment the patients were divided into 2 groups of 10 people each — main and control — using the method of randomisation envelopes. Patients of both main and control groups received complex conventional conservative treatment, but patients of the main group additionally received osteopathic correction. A total of 6 sessions with an interval of one month were conducted. The duration of each session was 60 minutes, the approach to each patient was individual. All patients before the beginning and after the completion of the course of treatment were assessed for osteopathic status, the severity of pain syndrome, ultrasonic diagnostics with evaluation of the biliary tract, biochemical blood analysis with evaluation of the level of total bilirubin. Results. The most frequently detected somatic dysfunctions (SD) in the observed patients were: lumbar region (both structural and visceral components — 100 %), neck region, visceral component (40 %), pelvic region, visceral component (30 %), dura mater region (30 %). In the same way, all patients were diagnosed with SD of local level. Among local dysfunctions it is worth mentioning: SD of spinal-motor segments of the thoracic spine (50 %), cervical spine (30 %), joints of the lower limbs (40 %), separate joints of the skull (10 %). On the background of the conducted treatment only in the patients of the main group a statistically significant (p