The pathogenesis of autoimmune diseases is very complex and multi-factorial. The concept of “Mosaics of Autoimmunity” was introduced to the scientific community 30 years ago by Y. Shoenfeld and D.A. Isenberg, and since then new tiles to the puzzle are continuously added. This concept specifies general pathological ideas about the multifactorial threshold model for polygenic inheritance with a threshold effect by the action of a number of external causal factors as applied to the field of autoimmunology. Among the external factors that can excessively stimulate the immune system, contributing to the development of autoimmune reactions, researchers are particularly interested in chemical substances, which are widely used in pharmacology and medicine. In this review we highlight the autoimmune dynamics - i.e. a multistep pathogenesis of autoimmune diseases and the subsequent development of lymphoma in some cases. In this context several issues are addressed - namely, genetic basis of autoimmunity; environmental
Translated title of the contributionHyperstimulation of the immune system as a cause of autoimmune diseases
Original languageRussian
Pages (from-to)204-213
Number of pages10
JournalVestnik Rossiiskoi Akademii Meditsinskikh Nauk
Volume75
Issue number3
DOIs
StatePublished - 2020

    Scopus subject areas

  • Medicine(all)

    Research areas

  • adjuvants, autoantibodies, autoimmunity, genetics, lymphoma, адъювант, аутоиммунитет, генетика, ингибиторы иммунных контрольных точек, лимфома

ID: 78289518