The article presents the results of a study of working conditions and a study of the morbidity of public civil servants in St. Petersburg based on statistical processing of the results of mandatory medical examinations in 2017, 2019 and 2023 for a total of 19797 people. It is determined that the working conditions of public civil servants, regardless of the sectoral sphere of the executive authority, are characterized by an increased level of risk factors for stressful situations that affect the occurrence of diseases and lead to deterioration of health. The structure of the main diseases of civil servants included: diseases of the eye and its accessory apparatus (21.51 %), diseases of the musculoskeletal system and connective tissue (21.15 %), diseases of the genitourinary system (10.98 %), diseases of the circulatory system (10.81 %), diseases of the endocrine system, eating disorders and metabolic disorders (9.19 %). The level of general morbidity of diseases of the circulatory system of civil servants of St. Petersburg statistically significantly exceeded the same indicator among the entire working-age population of the city in 2019 by 4.0 times and in 2023 by 2.8 times. The presented data indicate a significant influence of a complex of specific labor factors on the unfavorable dynamics in the structure and level of individual groups of diseases, which makes it advisable to timely identify and prevent the effects of these factors. Today, there is a need to establish hygienic standards for working conditions (service), and the development of medical prevention among government civil servants requires improvement through the development of programs to promote health and increase motivation to lead a healthy lifestyle, reduce the impact of stress factors.