TY - JOUR

T1 - Современные представления о контраст-индуцированном остром почечном повреждении

T2 - Взгляд интервенционного радиолога

AU - Хильчук, Антон Андреевич

AU - Щербак, Сергей Григорьевич

AU - Сарана, Андрей Михайлович

AU - Власенко, Сергей Васильевич

PY - 2017/10

Y1 - 2017/10

N2 - Clinically relevant contrast-induced acute kidney injury (CI-AKI) is a severe complication ofinterventional contrast-based procedures of all kinds. It is linked to high morbidity, mortality, social andfi nancial losses. Acute renal damage after coronary angiography or percutaneous coronary interventionmay occur in 1-2% cases in general population or in more than 50% of cases with high risk of developingCI-AKI. It is very important to identify existing compromised renal function in a high-risk patient, as it isa major and frequent CI-AKI predisposing factor. There are novel biomarkers with rapid or nearly instantresponse to acute subclinical contrast-induced renal damage, which are highly valuable in CI-AKI diagnosisand for this reason desire deeper clinical research. Despite a number of controversies, prophylactic andtherapeutic measures are practically the same in a vast majority of guidelines. Intravenous 0.9% NaClsolution remains one and only proved measure in CI-AKI prophylaxis and therapy, while the use of otherpharmacological approaches still needs more relevant prospective clinical research. The aim of this paperwas review contemporary, CI-AKI-devoted, evidence-based data.

AB - Clinically relevant contrast-induced acute kidney injury (CI-AKI) is a severe complication ofinterventional contrast-based procedures of all kinds. It is linked to high morbidity, mortality, social andfi nancial losses. Acute renal damage after coronary angiography or percutaneous coronary interventionmay occur in 1-2% cases in general population or in more than 50% of cases with high risk of developingCI-AKI. It is very important to identify existing compromised renal function in a high-risk patient, as it isa major and frequent CI-AKI predisposing factor. There are novel biomarkers with rapid or nearly instantresponse to acute subclinical contrast-induced renal damage, which are highly valuable in CI-AKI diagnosisand for this reason desire deeper clinical research. Despite a number of controversies, prophylactic andtherapeutic measures are practically the same in a vast majority of guidelines. Intravenous 0.9% NaClsolution remains one and only proved measure in CI-AKI prophylaxis and therapy, while the use of otherpharmacological approaches still needs more relevant prospective clinical research. The aim of this paperwas review contemporary, CI-AKI-devoted, evidence-based data.

KW - нефропатия

KW - повреждение почек

KW - контрастные вещества

KW - биомаркеры почечного повреждения

M3 - Обзорная статья

VL - 19

SP - 407

EP - 417

JO - Nephrology and Dialysis

JF - Nephrology and Dialysis

SN - 1680-4422

IS - 3

ER -