The article presents the results of a study of the problem of changing the content and conceptual structure of psychological knowledge in connection with modification through the technologies of the social and psychobiological mechanisms of the human psyche. The analysis of directions and technologies of techno-integration and techno-modification of the person is carried out. The philosophical and ethical problems of human techno-modification and its techno-integration with artificial global environments are considered. The emergence of new branches of psychology (synthetic psychology) associated with change and expansion through technologies of the social, sensory, intellectual and conscious spheres of man is shown.