Research output: Contribution to journal › Article › peer-review
Резолюция экспертного совета «Орнитин в онкологической практике». / Райхельсон, Карина Леонидовна; Оковитый, Сергей Владимирович; Надинская; Маевская, М.В.; Гладков, О. А.; Васенина; Гречишникова, В. Р.; Деева, Т. А.; Жаркова, М.С.; Осипенко, М.Ф.; Прашнова, Мария Константиновна; Приходько, Вероника.
In: МЕДИЦИНСКИЙ СОВЕТ, No. 8, 18.06.2025, p. 8-16.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Резолюция экспертного совета «Орнитин в онкологической практике»
AU - Райхельсон, Карина Леонидовна
AU - Оковитый, Сергей Владимирович
AU - Надинская,
AU - Маевская, М.В.
AU - Гладков, О. А.
AU - Васенина,
AU - Гречишникова, В. Р.
AU - Деева, Т. А.
AU - Жаркова, М.С.
AU - Осипенко, М.Ф.
AU - Прашнова, Мария Константиновна
AU - Приходько, Вероника
N1 - Оковитый СВ, Надинская МЮ, Маевская МВ, Гладков ОА, Васенина ЕЕ, Гречишникова ВР, Деева ТА, Жаркова МС, Осипенко МФ, Прашнова МК, Приходько ВА, Райхельсон КЛ. Резолюция экспертного совета «Орнитин в онкологической практике». Медицинский Совет. 2025;(8):8-16. https://doi.org/10.21518/ms2025-237
PY - 2025/6/18
Y1 - 2025/6/18
N2 - Among chemotherapy-related adverse events, drug-induced liver injury (DILI) is one of the most prevalent. In some cases, DILI is accompanied by hyperammonaemia (HA), which can disrupt chemotherapy cycles, and is associated with 25–45% mortality rates when specific antitumor agents are used. Efficacy studies in cancer patients were only found for ornithine (L-ornithine L-aspartate, LOLA) among all ammonia-lowering strategies. The amino acids in LOLA help to detoxify ammonia in the liver and other tissues, while also having several other metabolic effects. The experts expressed their viewpoints on the conducted studies, reviewed the main directions for applying LOLA in current clinical practice, and identified prospects for further research.
AB - Among chemotherapy-related adverse events, drug-induced liver injury (DILI) is one of the most prevalent. In some cases, DILI is accompanied by hyperammonaemia (HA), which can disrupt chemotherapy cycles, and is associated with 25–45% mortality rates when specific antitumor agents are used. Efficacy studies in cancer patients were only found for ornithine (L-ornithine L-aspartate, LOLA) among all ammonia-lowering strategies. The amino acids in LOLA help to detoxify ammonia in the liver and other tissues, while also having several other metabolic effects. The experts expressed their viewpoints on the conducted studies, reviewed the main directions for applying LOLA in current clinical practice, and identified prospects for further research.
UR - https://www.mendeley.com/catalogue/00e94dc5-ed50-3198-82c8-813e5c1e920f/
U2 - 10.21518/ms2025-237
DO - 10.21518/ms2025-237
M3 - статья
SP - 8
EP - 16
JO - МЕДИЦИНСКИЙ СОВЕТ
JF - МЕДИЦИНСКИЙ СОВЕТ
SN - 2079-7028
IS - 8
ER -
ID: 137333452