The article reveals the problems of determining the limits of the legal regulation of social relations in connection with the inclusion in the subject of legal regulation of relations between subjects and human activities in the technosphere, the sphere of anthropogenic impact on the environment. The author shows that as a result of the "technicalization" of social relations, new methods of legal impact are emerging, the effectiveness of which is determined, in particular, by various mathematical criteria (impact indicators), as well as new forms of legal regulations expressing techno-anthropogenic requirements using tables, columns, graphs and other "non-standard" methods of presentation of legal rules. According to the author of the article, legal regulation should cover in modern conditions social relations in the technosphere, the sphere of anthropogenic impact on the environment (environmental impact) in order to prevent negative changes in the ecosystem. The expansion (universalization) of the technogenic and environmental spheres of social relations leads, as shown in the article, to the need for state-legal interference in the regulation of issues of scientific and technical, research activities, technological production processes, activities related to the use of new technologies, for example, in health care.