Rationale. Breast cancer (BC) today is the leading oncologic pathology in Russia. The use of new treatments is associated with high healthcare costs. The epidemiological forecast and cost planning are not possible without the building of the mathematical model of BC. Aim. The perform a literature review of BC models. Materials and methods. The systematic literature review was performed by searching databases (PubMed). From 547 initially got publications 20 were included in the analysis. Not included publications could be divided into groups: pharmacoeconomic model of particular drug, BC screening models, model of tumor growth, models of ВС imaging (US, MRI). Results. BC epidemiologic mathematical model should be based on the patient data from national register, the time horizon should be not less than 5 years, it should be based on Markov modelling and be non-homogenous. The model has to differentiate several tumor types and disease stage. Conclusion. Today in Russia there is no epidemiologic mathematical model of BC.