The article in a review form gives a modern view on the interaction of a silicone implant (endoprosthesis) of the mammary gland and the human body with an emphasis on possible systemic reactions. It shows a current view on the possible formation of antibodies and auto­antibodies as a typical immune response to an ­alien body is presented. In the article have been analyzed known clini­cal manifestations of systemic reactions to silicone. It is shown that this process is a particular case of the ASIA syndrome (an autoimmune inflammatory adjuvant-­associated syndrome), which unites immune-­associated diseases stimulated by adjuvants in people who are potentially prone to these diseases. The possible role of the major histocompatibility complex is emphasized, as a key genetic factor in the development of this syndrome when exposed to an adjuvant (silicone) and the environment. It is concluded that the selection of a group of patients is promising in which it is possible to predict the development of this syndrome in response to silicone prosthetics.