The article presents the results of threeyear experimental and clinical studies on the use of allogeneic adipogenic mesenchymal stem cells in the treatment of skin burns of the II-III degree both in experiment and in clinical practice. Objective: to develop promising methods of treating victims of thermal injury through the use of biomedical cell products containing mesenchymal stem cells. Materials and methods: the clinical and experimental sections are presented in the work. The first one was attended by more than 30 victims with burns of various depths aged 23 to 65 years. The second was performed using 48 small laboratory animals weighing 230-250 g. The effectiveness of the applied methods included an objective examination of the wound burn surface, planimetry, microbiological examination of the discharge, subjective patient data, and laboratory results. The safety of the drug was evaluated on the basis of an analysis of objective and subjective state data, the dynamics of laboratory parameters and the frequency of occurrence of adverse events. Results: evaluation of the effectiveness of biomedical cell products with stem cells collagen cellular complex product (gel for local application) and multipotent mesenchymal stem cells (for injection) demonstrates their ability to optimize reparative regeneration in the area of burn lesions. It was found that the use of this drug reduces the time of final healing by 47%, while the complication rate did not exceed 12.5%. In experimental work, it was also demonstrated that the use of products containing mesenchymal stem cells in combination with early necrectomy and coatings based on natural polymers can accelerate tissue regeneration by 91.2%. The results of immunohistochemical studies confirm the optimization of the processes of reparative regeneration in the area of application of biomedical cell products by stimulating the expression of proliferation markers up to 460%, while the level of tissue perfusion also increased by 2 times. Conclusion: the use of biomedical cell products in assisting victims with burns allows not only to improve the results of their treatment, but also to increase the effectiveness of methods for surgical restoration of the skin (4 figs, 1 table, bibliography: 4 refs).