Research output: Contribution to journal › Review article › peer-review
Факторы риска развития метастатической феохромоцитомы\параганглиомы. / Реброва, Дина Владимировна; Логинова, Ольга Ивановна; Воробьев, Сергей Леонидович; Ворохобина, Наталья Владимировна; Савельева, Татьяна Вячеславовна; Слепцов, Илья Валерьевич; Черников, Роман Анатольевич; Федоров, Елисей Александрович; Семенов, Арсений Андреевич; Чинчук, Игорь Константинович; Шихмагомедов, Шамиль Шамсудинович; Алексеев, Михаил Александрович; Краснов , Леонид Михайлович; Русаков, Владимир Федорович.
In: ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ, Vol. 70, No. 2, 2024, p. 37-45.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Факторы риска развития метастатической феохромоцитомы\параганглиомы
AU - Реброва, Дина Владимировна
AU - Логинова, Ольга Ивановна
AU - Воробьев, Сергей Леонидович
AU - Ворохобина, Наталья Владимировна
AU - Савельева, Татьяна Вячеславовна
AU - Слепцов, Илья Валерьевич
AU - Черников, Роман Анатольевич
AU - Федоров, Елисей Александрович
AU - Семенов, Арсений Андреевич
AU - Чинчук, Игорь Константинович
AU - Шихмагомедов, Шамиль Шамсудинович
AU - Алексеев, Михаил Александрович
AU - Краснов , Леонид Михайлович
AU - Русаков, Владимир Федорович
PY - 2024
Y1 - 2024
N2 - Currently, all pheochromocytoma/paraganglioma (PPGLs) are considered malignant due to metastatic potential. Consequently, PPGLs are divided into «metastatic» and «non-metastatic». Metastatic PPGLs can be with synchronous metastasis (metastases appear simultaneously with the identified primary tumor) or metachronous (metastases develop after removal of the primary tumor). The term metastatic PPGLs is not used in the presence of tumor invasion into surrounding organs and tissues, without the presence of distant metastases of lymphogenic or hematogenic origin. It is generally believed that about 10% of pheochromocytomas and about 40% of sympathetic paragangliomas have metastatic potential. On average, the prevalence of PPGLs with the presence of metastases is 15-20%. Risk factors for metastatic PPGLs are widely discussed in the literature, the most significant of which are groups of clinical, morphological and genetic characteristics. The review presents a discussion of such risk factors for metastatic PPGLs as age, localization and type of hormonal secretion of the tumor, the size and growth pattern of the adrenal lesion, the presence of necrosis and invasion into the vessels, the tumor capsule surrounding adipose tissue, high cellular and mitotic activity, Ki-67 index, expression of chromogranin B and S100 protein, the presence of genetic mutations of three main clusters (pseudohypoxia, kinase signaling and Wnt signaling).Over the past two decades, a number of authors have proposed various predictor factors and scales for assessing a probability of metastatic PPGLs. The review contains detailed description and comparison of sensitivity and specificity of such predictor scales as PASS, GAPP, M-GAPP, ASES and COPPS.
AB - Currently, all pheochromocytoma/paraganglioma (PPGLs) are considered malignant due to metastatic potential. Consequently, PPGLs are divided into «metastatic» and «non-metastatic». Metastatic PPGLs can be with synchronous metastasis (metastases appear simultaneously with the identified primary tumor) or metachronous (metastases develop after removal of the primary tumor). The term metastatic PPGLs is not used in the presence of tumor invasion into surrounding organs and tissues, without the presence of distant metastases of lymphogenic or hematogenic origin. It is generally believed that about 10% of pheochromocytomas and about 40% of sympathetic paragangliomas have metastatic potential. On average, the prevalence of PPGLs with the presence of metastases is 15-20%. Risk factors for metastatic PPGLs are widely discussed in the literature, the most significant of which are groups of clinical, morphological and genetic characteristics. The review presents a discussion of such risk factors for metastatic PPGLs as age, localization and type of hormonal secretion of the tumor, the size and growth pattern of the adrenal lesion, the presence of necrosis and invasion into the vessels, the tumor capsule surrounding adipose tissue, high cellular and mitotic activity, Ki-67 index, expression of chromogranin B and S100 protein, the presence of genetic mutations of three main clusters (pseudohypoxia, kinase signaling and Wnt signaling).Over the past two decades, a number of authors have proposed various predictor factors and scales for assessing a probability of metastatic PPGLs. The review contains detailed description and comparison of sensitivity and specificity of such predictor scales as PASS, GAPP, M-GAPP, ASES and COPPS.
KW - Adrenal Gland Neoplasms/pathology
KW - Humans
KW - Neoplasm Metastasis
KW - Paraganglioma/pathology
KW - Pheochromocytoma/pathology
KW - Risk Factors
KW - GAPP scale
KW - PASS scale
KW - malignant pheochromocytoma/paraganglioma
KW - metastatic pheochromocytoma/paraganglioma
KW - paraganglioma
KW - pheochromocytoma
UR - https://www.mendeley.com/catalogue/40cfa46e-a9f7-3565-b027-d26830d891bc/
U2 - 10.14341/probl13331
DO - 10.14341/probl13331
M3 - Обзорная статья
C2 - 38796759
VL - 70
SP - 37
EP - 45
JO - ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ
JF - ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ
SN - 0375-9660
IS - 2
ER -
ID: 125113527