Research output: Contribution to journal › Review article › peer-review
Гемистоцитарные астроцитомы. / Matsko, D. E.; Zrelov, A. A.; Ulitin, A. Yu; Matsko, M. V.; Skliar, S. S.; Baksheeva, A. O.; Imyanitov, E. N.
In: АРХИВ ПАТОЛОГИИ, Vol. 80, No. 4, 2018, p. 27-38.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Гемистоцитарные астроцитомы
AU - Matsko, D. E.
AU - Zrelov, A. A.
AU - Ulitin, A. Yu
AU - Matsko, M. V.
AU - Skliar, S. S.
AU - Baksheeva, A. O.
AU - Imyanitov, E. N.
N1 - Publisher Copyright: © 2018 Media Sphera Publishing Group. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Gemistocytic astrocytomas (GA) are a variant of diffuse astrocytomas GII (WHO, 2016). Like all diffuse astrocytomas, GA recur with time, which is often accompanied by malignant degeneretion into the anaplastic astrocytoma GIII or to the secondary glioblastoma GIV. However, the progression-free survival and overall survival in patients with GA is less than in patients with diffuse astrocytomas. Given that this group of patients, according to the WHO classification (2016), is classified as GII, patients with GA usually do not receive comprehensive treatment. We have conducted a thorough analysis of research on this problem for the period from 1956 to 2017. Differences in the histological pattern, immunohistochemical and molecular-genetic profiles, survival of patients with GA and diffuse astrocytomas GII are shown there. A clinical case of a patient with transformation of a diffuse astrocytoma in GA (GIII) and then into a secondary glioblastoma is presented.
AB - Gemistocytic astrocytomas (GA) are a variant of diffuse astrocytomas GII (WHO, 2016). Like all diffuse astrocytomas, GA recur with time, which is often accompanied by malignant degeneretion into the anaplastic astrocytoma GIII or to the secondary glioblastoma GIV. However, the progression-free survival and overall survival in patients with GA is less than in patients with diffuse astrocytomas. Given that this group of patients, according to the WHO classification (2016), is classified as GII, patients with GA usually do not receive comprehensive treatment. We have conducted a thorough analysis of research on this problem for the period from 1956 to 2017. Differences in the histological pattern, immunohistochemical and molecular-genetic profiles, survival of patients with GA and diffuse astrocytomas GII are shown there. A clinical case of a patient with transformation of a diffuse astrocytoma in GA (GIII) and then into a secondary glioblastoma is presented.
KW - Diffuse astrocytoma
KW - Gemistocytic astrocytoma
KW - Molecular-genetic features
UR - http://www.scopus.com/inward/record.url?scp=85050795930&partnerID=8YFLogxK
U2 - 10.17116/patol201880427
DO - 10.17116/patol201880427
M3 - Обзорная статья
C2 - 30059069
AN - SCOPUS:85050795930
VL - 80
SP - 27
EP - 38
JO - АРХИВ ПАТОЛОГИИ
JF - АРХИВ ПАТОЛОГИИ
SN - 0004-1955
IS - 4
ER -
ID: 39064719