Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Water-Soluble Fullerene C60 Derivatives Are Effective Inhibitors of Influenza Virus Replication. / Sinegubova, Ekaterina O. ; Kraevaya, Olga A. ; Volobueva, Aleksandrina S. ; Zhilenkov, Alexander V. ; Shestakov, Alexander F. ; Baykov, Sergey V. ; Troshin, Pavel A.; Zarubaev, Vladimir V. .
в: Microorganisms, Том 11, № 3, 681, 07.03.2023.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Water-Soluble Fullerene C60 Derivatives Are Effective Inhibitors of Influenza Virus Replication
AU - Sinegubova, Ekaterina O.
AU - Kraevaya, Olga A.
AU - Volobueva, Aleksandrina S.
AU - Zhilenkov, Alexander V.
AU - Shestakov, Alexander F.
AU - Baykov, Sergey V.
AU - Troshin, Pavel A.
AU - Zarubaev, Vladimir V.
N1 - Sinegubova, E.O.; Kraevaya, O.A.; Volobueva, A.S.; Zhilenkov, A.V.; Shestakov, A.F.; Baykov, S.V.; Troshin, P.A.; Zarubaev, V.V. Water-Soluble Fullerene C60 Derivatives Are Effective Inhibitors of Influenza Virus Replication. Microorganisms 2023, 11, 681. https://doi.org/10.3390/microorganisms11030681
PY - 2023/3/7
Y1 - 2023/3/7
N2 - The influenza virus genome features a very high mutation rate leading to the rapid selection of drug-resistant strains. Due to the emergence of drug-resistant strains, there is a need for the further development of new potent antivirals against influenza with a broad activity spectrum. Thus, the search for a novel, effective broad-spectrum antiviral agent is a top priority of medical science and healthcare systems. In this paper, derivatives based on fullerenes with broad virus inhibiting activities in vitro against a panel of influenza viruses were described. The antiviral properties of water-soluble fullerene derivatives were studied. It was demonstrated that the library of compounds based on fullerenes has cytoprotective activity. Maximum virus-inhibiting activity and minimum toxicity were found with compound 2, containing residues of salts of 2-amino-3-cyclopropylpropanoic acid (CC50 > 300 µg/mL, IC50 = 4.73 µg/mL, SI = 64). This study represents the initial stage in a study of fullerenes as anti-influenza drugs. The results of the study lead us conclude that five leading compounds (1–5) have pharmacological prospects.
AB - The influenza virus genome features a very high mutation rate leading to the rapid selection of drug-resistant strains. Due to the emergence of drug-resistant strains, there is a need for the further development of new potent antivirals against influenza with a broad activity spectrum. Thus, the search for a novel, effective broad-spectrum antiviral agent is a top priority of medical science and healthcare systems. In this paper, derivatives based on fullerenes with broad virus inhibiting activities in vitro against a panel of influenza viruses were described. The antiviral properties of water-soluble fullerene derivatives were studied. It was demonstrated that the library of compounds based on fullerenes has cytoprotective activity. Maximum virus-inhibiting activity and minimum toxicity were found with compound 2, containing residues of salts of 2-amino-3-cyclopropylpropanoic acid (CC50 > 300 µg/mL, IC50 = 4.73 µg/mL, SI = 64). This study represents the initial stage in a study of fullerenes as anti-influenza drugs. The results of the study lead us conclude that five leading compounds (1–5) have pharmacological prospects.
KW - influenza virus
KW - HEMAGGLUTININ
KW - antiviral agent
KW - fullerene
UR - https://www.mdpi.com/2076-2607/11/3/681
M3 - Article
VL - 11
JO - Microorganisms
JF - Microorganisms
SN - 2076-2607
IS - 3
M1 - 681
ER -
ID: 103444523