Water-Soluble Form of 1-Alkyl(Aryl)Imidazole-4,5-Dicarboxylic Acids. Structure and Anticonvulsant Activity of the Triethanolammonium Salt of 1-Propylimidazole-4,5-Dicarboxylic Acid

M. A. Brusina, D. N. Nikolaev, V. S. Fundamenskii, V. V. Gurzhii, A. A. Zolotarev, A. V. Selitrenikov, Yu Zevatskii, A. M. Potapkin, S. M. Ramsh, L. B. Piotrovskii

Результат исследований: Научные публикации в периодических изданияхстатья

1 Цитирования (Scopus)

Аннотация

Water-soluble forms of a series of 1-alkyl(aryl)imidazole-4,5-dicarboxylic acids were prepared. Anticonvulsant activity of 1-propylimidazole-4,5-dicarboxylic acid and its triethanolammonium salt was studied using the NMDA-induced convulsion model. The triethanolammonium salt of 1-propylimidazole-4,5-dicarboxylic acid was shown to possess anticonvulsant activity whereas the acid itself was a convulsant. The change of pharmacological profile was related to the formation of ion pairs or associates even in polar physiological media. The ability to associate was confirmed using conductivity measurements. An x-ray crystal structure analysis was performed for the triethanolammonium salt of 1-propylimidazole-4,5-dicarboxylic acid.

Язык оригиналаанглийский
Страницы (с-по)299-303
Число страниц5
ЖурналPharmaceutical Chemistry Journal
Том52
Номер выпуска4
DOI
СостояниеОпубликовано - 1 июл 2018

    Fingerprint

Предметные области Scopus

  • Фармакология
  • Поиск новых лекарств

Цитировать