Understanding neurobehavioral genetics of zebrafish

Sergey V. Cheresiz, Andrey D Volgin, Alexandra Kokorina Evsyukova, Alim A. O. Bashirzade, Konstantin A. Demin, Murilo S. de Abreu, Tamara G Amstislavskaya, Allan V. Kalueff

Результат исследований: Научные публикации в периодических изданияхОбзорная статьярецензирование

3 Цитирования (Scopus)

Аннотация

Due to its fully sequenced genome, high genetic homology to humans, external fertilization, fast development, transparency of embryos, low cost and active reproduction, the zebrafish (Danio rerio) has become a novel promising model organism in biomedicine. Zebrafish are a useful tool in genetic and neuroscience research, including linking various genetic mutations to brain mechanisms using forward and reverse genetics. These approaches have produced novel models of rare genetic CNS disorders and common brain illnesses, such as addiction, aggression, anxiety and depression. Genetically modified zebrafish also foster neuroanatomical studies, manipulating neural circuits and linking them to different behaviors. Here, we discuss recent advances in neurogenetics of zebrafish, and evaluate their unique strengths, inherent limitations and the rapidly growing potential for elucidating the conserved roles of genes in neuropsychiatric disorders.

Язык оригиналаанглийский
Число страниц13
ЖурналJournal of Neurogenetics
Ранняя дата в режиме онлайн5 янв 2020
DOI
СостояниеОпубликовано - янв 2020

Предметные области Scopus

  • Генетика
  • Клеточная и молекулрная нейробиология

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