Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models.

J. R. Homberg, E. J. Kyzar, M. Nguyen, W. H. Norton, J. Pittman, M. K. Poudel, S. Gaikwad, S. Nakamura, M. Koshiba, H. Yamanouchi, M. L. Scattoni, J. F. Ullman, D. M. Diamond, A. A. Kaluyeva, M. O. Parker, V. M. Klimenko, S. A. Apryatin, R. E. Brown, C. Song, R. R. GainetdinovI. I. Gottesman, A. V. Kalueff

Результат исследований: Научные публикации в периодических изданияхОбзор литературы

23 Цитирования (Scopus)

Выдержка

Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize h
Язык оригиналаанглийский
Страницы (с-по)292-312
ЖурналNeuroscience and Biobehavioral Reviews
Номер выпуска65
DOI
СостояниеОпубликовано - 2016

Отпечаток

Autistic Disorder
Tic Disorders
Communication Disorders
Speech Disorders
Neurogenesis
Brain
Attention Deficit Disorder with Hyperactivity
Growth and Development
Epigenomics
Neuroglia
Intellectual Disability
Synapses
Neurodevelopmental Disorders
Rodentia
Language
Animal Models
Research

Цитировать

Homberg, J. R. ; Kyzar, E. J. ; Nguyen, M. ; Norton, W. H. ; Pittman, J. ; Poudel, M. K. ; Gaikwad, S. ; Nakamura, S. ; Koshiba, M. ; Yamanouchi, H. ; Scattoni, M. L. ; Ullman, J. F. ; Diamond, D. M. ; Kaluyeva, A. A. ; Parker, M. O. ; Klimenko, V. M. ; Apryatin, S. A. ; Brown, R. E. ; Song, C. ; Gainetdinov, R. R. ; Gottesman, I. I. ; Kalueff, A. V. / Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models. В: Neuroscience and Biobehavioral Reviews. 2016 ; № 65. стр. 292-312.
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title = "Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models.",
abstract = "Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize h",
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author = "Homberg, {J. R.} and Kyzar, {E. J.} and M. Nguyen and Norton, {W. H.} and J. Pittman and Poudel, {M. K.} and S. Gaikwad and S. Nakamura and M. Koshiba and H. Yamanouchi and Scattoni, {M. L.} and Ullman, {J. F.} and Diamond, {D. M.} and Kaluyeva, {A. A.} and Parker, {M. O.} and Klimenko, {V. M.} and Apryatin, {S. A.} and Brown, {R. E.} and C. Song and Gainetdinov, {R. R.} and Gottesman, {I. I.} and Kalueff, {A. V.}",
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Homberg, JR, Kyzar, EJ, Nguyen, M, Norton, WH, Pittman, J, Poudel, MK, Gaikwad, S, Nakamura, S, Koshiba, M, Yamanouchi, H, Scattoni, ML, Ullman, JF, Diamond, DM, Kaluyeva, AA, Parker, MO, Klimenko, VM, Apryatin, SA, Brown, RE, Song, C, Gainetdinov, RR, Gottesman, II & Kalueff, AV 2016, 'Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models.', Neuroscience and Biobehavioral Reviews, № 65, стр. 292-312. https://doi.org/10.1016/j.neubiorev.2016.03.013

Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models. / Homberg, J. R.; Kyzar, E. J.; Nguyen, M.; Norton, W. H.; Pittman, J.; Poudel, M. K.; Gaikwad, S.; Nakamura, S.; Koshiba, M.; Yamanouchi, H.; Scattoni, M. L.; Ullman, J. F.; Diamond, D. M.; Kaluyeva, A. A.; Parker, M. O.; Klimenko, V. M.; Apryatin, S. A.; Brown, R. E.; Song, C.; Gainetdinov, R. R.; Gottesman, I. I.; Kalueff, A. V.

В: Neuroscience and Biobehavioral Reviews, № 65, 2016, стр. 292-312.

Результат исследований: Научные публикации в периодических изданияхОбзор литературы

TY - JOUR

T1 - Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models.

AU - Homberg, J. R.

AU - Kyzar, E. J.

AU - Nguyen, M.

AU - Norton, W. H.

AU - Pittman, J.

AU - Poudel, M. K.

AU - Gaikwad, S.

AU - Nakamura, S.

AU - Koshiba, M.

AU - Yamanouchi, H.

AU - Scattoni, M. L.

AU - Ullman, J. F.

AU - Diamond, D. M.

AU - Kaluyeva, A. A.

AU - Parker, M. O.

AU - Klimenko, V. M.

AU - Apryatin, S. A.

AU - Brown, R. E.

AU - Song, C.

AU - Gainetdinov, R. R.

AU - Gottesman, I. I.

AU - Kalueff, A. V.

PY - 2016

Y1 - 2016

N2 - Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize h

AB - Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize h

KW - Experimental model

KW - Model organism

KW - Neurodevelopmental disorder

KW - Preclinical study

KW - Translational research

U2 - 10.1016/j.neubiorev.2016.03.013

DO - 10.1016/j.neubiorev.2016.03.013

M3 - Literature review

SP - 292

EP - 312

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

IS - 65

ER -