Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models

Константин Забегалов, Татьяна Колесникова, Сергей Хацко, Андрей Волгин, Олег Яковлев, Тамара Амстиславская, Полина Алексеева, Дарья Андреевна Мешалкина, Ashton Friend, Wandong Bao, Константин Андреевич Демин, Рауль Радикович Гайнетдинов, Алан Валерьевич Калуев

Результат исследований: Научные публикации в периодических изданияхОбзорная статьярецензирование

7 Цитирования (Scopus)

Аннотация

Antidepressant drugs are currently one of the most prescribed medications. In addition to treatment resistance and side effects of antidepressants, their clinical use is further complicated by antidepressant discontinuation syndrome (ADS). ADS is a common problem in patients following the interruption, dose reduction, or discontinuation of antidepressant drugs. Clinically, ADS resembles a classical drug withdrawal syndrome, albeit differing from it because antidepressants generally do not induce addiction. The growing clinical importance and prevalence of ADS necessitate novel experimental (animal) models of this disorder. Currently available preclinical models of ADS are mainly rodent-based, and study mostly serotonergic antidepressants and their combinations. Here, we systematically assess clinical ADS symptoms and discuss current trends and challenges in the field of experimental (animal) models of ADS. We also outline basic mechanisms underlying ADS pathobiology, evaluate its genetic, pharmacological and environmental determinants, and emphasize how using animal models may help generate important translational insights into human ADS condition, its prevention and therapy.
Язык оригиналаанглийский
Страницы (с-по)129-140
Число страниц12
ЖурналEuropean Journal of Pharmacology
Том829
DOI
СостояниеОпубликовано - 15 июн 2018

Предметные области Scopus

  • Фармакология

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