Understanding antideppressant discontinuation syndrome (asd) – bridging clinical and preclinical findings

Константин Забегалов, Татьяна Колесникова, Сергей Хацко, Андрей Волгин, Олег Яковлев, Тамара Амстиславская, Полина Алексеева, Дарья Андреевна Мешалкина, Ashton Friend, Wandong Bao, Константин Андреевич Демин, Алан Валерьевич Калуев

Результат исследований: Материалы конференцийтезисырецензирование

Аннотация

Antidepressant drugs are currently the most prescribed class of medications. In addition to treatment resistance and side effects of antidepressants, their clinical use is further complicated by antidepressant discontinuation syndrome (ADS). ADS typically occurs in patients following the interruption, dose reduction, or discontinuation of antidepressant drugs. ADS resembles a classical drug withdrawal syndrome, albeit differing from it because antidepressants generally do not induce addiction. The growing clinical importance and prevalence of ADS necessitate novel experimental (animal) models of this disorder. Currently available preclinical models of ADS are mainly rodent-based, and study mostly serotonergic antidepressants and their combinations. Here, we systematically assess clinical ADS symptoms and discuss current trends and challenges in the field of experimental (animal) models of ADS. We also outline basic mechanisms underlying ADS pathobiology, evaluate its genetic, pharmacological and environmental determinants, and suggest how using animal models of ADS may help generate important translational insights into human ADS condition, its prevention and therapy.
Язык оригиналаанглийский
СостояниеОпубликовано - 16 июн 2018
Событие5th Caribbean Biomedical Research Days CBRD-2018 - Rodney Bay, St. Lucia, Сент-Люсия
Продолжительность: 16 янв 201818 янв 2018

конференция

конференция5th Caribbean Biomedical Research Days CBRD-2018
СтранаСент-Люсия
Период16/01/1818/01/18

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