Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

Nataliia Sergeevna Novikova, Anastasiia Sergeevna Diatlova, Kristina Zurabovna Derevtsova, Elena Andreevna Korneva, Tamara Viktorovna Fedotkina, Yuri Ostrinki, Lital Abraham, Shir Quinn, Yahel Segal, Leonid Churilov, Miri Blank, Yehuda Shoenfeld, Rina Aharoni, Howard Amital

Результат исследований: Научные публикации в периодических изданияхстатья

Аннотация

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.

Язык оригиналаанглийский
Страницы (с-по)577070
ЖурналJournal of Neuroimmunology
Том337
Ранняя дата в режиме онлайн24 окт 2019
DOI
СостояниеОпубликовано - дек 2019

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