TY - JOUR

T1 - Trifluoperazine attenuates store-dependent Ca2+ entry in macrophages

AU - Krutetskaya, Z. I.

AU - Milenina, L. S.

AU - Naumova, A. A.

AU - Butov, S. N.

AU - Antonov, V. G.

AU - Nozdrachev, A. D.

N1 - Krutetskaya Z.I., Milenina L. S., Naumova A.A., Butov S.N., Antonov V.G., Nozdrachev A.D. 2018. Thrifluoperazine attenuates store-dependent Ca2+ entry in macrophages. Doklady Biochemistry and Biophysics. 478: 1 - 3.

PY - 2018

Y1 - 2018

N2 - Using Fura-2AM microfluorimetry, we have shown for the first time that preincubation of macrophages with the calsequestrin inhibitor neuroleptic trifluoperazine leads to a significant inhibition of the store-dependent Ca 2+ entry induced by endoplasmic Ca 2+-ATPase inhibitors thapsigargin or cyclopiazonic acid in rat peritoneal macrophages. The results suggest calsequestrin involvement in the regulation of the store-dependent Ca 2+ entry in macrophages.

AB - Using Fura-2AM microfluorimetry, we have shown for the first time that preincubation of macrophages with the calsequestrin inhibitor neuroleptic trifluoperazine leads to a significant inhibition of the store-dependent Ca 2+ entry induced by endoplasmic Ca 2+-ATPase inhibitors thapsigargin or cyclopiazonic acid in rat peritoneal macrophages. The results suggest calsequestrin involvement in the regulation of the store-dependent Ca 2+ entry in macrophages.

KW - AGGREGATION

KW - CALSEQUESTRIN

KW - INHIBITORS

KW - OPERATED CALCIUM-CHANNELS

KW - SKELETAL-MUSCLE

UR - http://www.scopus.com/inward/record.url?scp=85043992504&partnerID=8YFLogxK

U2 - 10.1134/S1607672918010143

DO - 10.1134/S1607672918010143

M3 - Article

VL - 478

SP - 44

EP - 46

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -