Transcriptional changes in bone marrow stromal cells of patients with heart failure

I.R. Minullina, N.P. Alexeyeva, S.V. Anisimov, M.V. Puzanov, S.N. Kozlova, Y.V. Sviryaev, A.Y. Zaritskey, E.V. Shlyakhto

Результат исследований: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Аннотация

It is proposed that patients with heart failure may have not only myocardial dysfunction, but also a reduced regenerative capacity of stem cells. However, very little is known about bone marrow stromal cell (BMSC) characteristics in heart failure and its comorbidities (obesity and/or diabetes). We hypothesized that metabolic alterations associated with the latter will be reflected in altered expression of key genes related to angiogenesis, inflammation, and tissue remodeling in patient-derived BMSCs. We found that BMSCs of heart failure patients with lower body mass index have enhanced expression of genes involved in extracellular matrix remodeling. In particular, body mass index
Язык оригиналаанглийский
Страницы (с-по)1495-1500
ЖурналCell Cycle
Том13
Номер выпуска9
DOI
СостояниеОпубликовано - 2014

    Fingerprint

Цитировать

Minullina, I. R., Alexeyeva, N. P., Anisimov, S. V., Puzanov, M. V., Kozlova, S. N., Sviryaev, Y. V., ... Shlyakhto, E. V. (2014). Transcriptional changes in bone marrow stromal cells of patients with heart failure. Cell Cycle, 13(9), 1495-1500. https://doi.org/10.4161/cc.28472