Towards the zebrafish-based models for personalized psychiatry - insights from individual, strain and gender differences, and modeling gene x environment interactions

Андрей Волгин, Олег Яковлев, Константин Андреевич Демин, Murilo de Abreu, Полина Алексеева, Ashton Friend, Тамара Амстиславская, Алан Валерьевич Калуев

Результат исследований: Материалы конференцийтезисырецензирование

Аннотация

Currently becoming widely recognized, personalized psychiatry focuses on patients’ unique physiological and genetic profiles to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remain poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing and high physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence support zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain and sex differences shape their CNS responses to genetic, environmental and pharmacological manipulations. Here, we discuss zebrafish as a promising translational tool to further advance patient-centered personalized psychiatry.
Язык оригиналаанглийский
Страницы45
СостояниеОпубликовано - 16 мая 2018
Событие25th Multidisciplinary International Neuroscience and Biological Psychiatry Conference “Stress and Behavior”: International Stress and Behavior Society Conference - St.Petersburg, St.Petersburg, Российская Федерация
Продолжительность: 16 мая 201819 мая 2018
Номер конференции: 25
http://iemspb.ru/event/25th-international-multidisciplinary-neuroscience-and-biological-psychiatry-stress-and-behavior-conference/
http://biomedinstitute.spbu.ru/ru/node/153

конференция

конференция25th Multidisciplinary International Neuroscience and Biological Psychiatry Conference “Stress and Behavior”
Сокращенный заголовок ISBS
СтранаРоссийская Федерация
ГородSt.Petersburg
Период16/05/1819/05/18
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