The Structural and Functional Characteristics of Rat Soleus Endplates under Short-Term Disruption of Motor Activity

V. V.  Kravtsova; E. A.  Saburova; I. I.  Krivoi

doi:10.1134/S0006350919050129

The Structural and Functional Characteristics of Rat Soleus Endplates under Short-Term Disruption of Motor Activity

V. V. Kravtsova, E. A. Saburova, I. I. Krivoi

Кафедра общей физиологии

Результат исследований: Научные публикации в периодических изданиях › статья

Аннотация

In this study we analyzed the distribution of nicotinic acetylcholine receptors, the degree of their
fragmentation, endplate area, and membrane localization of the α2 isoform of the Na,K–ATPase in the rat
soleus muscle after functional unloading (via the method of hindlimb suspension) for 1–3 days. After unloading
increased endplate fragmentation accompanied by a decrease in the area of individual fragments was
observed; the total area of the endplates did not change. The density of distribution of nicotinic acetylcholine
receptors also remained unaltered; however, the density of the distribution of the α2 isoform of the Na,K–
ATPase significantly decreased. Presumably, these changes resulted from adaptive skeletal muscle remodeling,
which develops not only during chronic disorders, but even in the early stages of motor dysfunction.

Язык оригинала	английский
Страницы (с-по)	772–776
Журнал	Biophysics (Russian Federation)
Том	64
Номер выпуска	5
DOI	https://doi.org/10.1134/S0006350919050129
Состояние	Опубликовано - дек 2019

Ключевые слова

motor endplate, nicotinic acetylcholine receptor, Na,K-ATPase isoforms, motor activity

Доступ к документу

10.1134/S0006350919050129

http://www.scopus.com/inward/record.url?scp=85076485835&partnerID=8YFLogxK

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abstract = "In this study we analyzed the distribution of nicotinic acetylcholine receptors, the degree of their fragmentation, endplate area, and membrane localization of the α2 isoform of the Na,K–ATPase in the rat soleus muscle after functional unloading (via the method of hindlimb suspension) for 1–3 days. After unloading increased endplate fragmentation accompanied by a decrease in the area of individual fragments was observed; the total area of the endplates did not change. The density of distribution of nicotinic acetylcholine receptors also remained unaltered; however, the density of the distribution of the α2 isoform of the Na,K– ATPase significantly decreased. Presumably, these changes resulted from adaptive skeletal muscle remodeling, which develops not only during chronic disorders, but even in the early stages of motor dysfunction.",

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The Structural and Functional Characteristics of Rat Soleus Endplates under Short-Term Disruption of Motor Activity. / Kravtsova, V. V. ; Saburova, E. A. ; Krivoi, I. I. .

В: Biophysics (Russian Federation), Том 64, № 5, 12.2019, стр. 772–776.

Результат исследований: Научные публикации в периодических изданиях › статья

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