The Structural and Functional Characteristics of Rat Soleus Endplates under Short-Term Disruption of Motor Activity

Результат исследований: Научные публикации в периодических изданияхстатья

Аннотация

In this study we analyzed the distribution of nicotinic acetylcholine receptors, the degree of their
fragmentation, endplate area, and membrane localization of the α2 isoform of the Na,K–ATPase in the rat
soleus muscle after functional unloading (via the method of hindlimb suspension) for 1–3 days. After unloading
increased endplate fragmentation accompanied by a decrease in the area of individual fragments was
observed; the total area of the endplates did not change. The density of distribution of nicotinic acetylcholine
receptors also remained unaltered; however, the density of the distribution of the α2 isoform of the Na,K–
ATPase significantly decreased. Presumably, these changes resulted from adaptive skeletal muscle remodeling,
which develops not only during chronic disorders, but even in the early stages of motor dysfunction.
Язык оригиналаанглийский
Страницы (с-по)772–776
ЖурналBiophysics (Russian Federation)
Том64
Номер выпуска5
DOI
СостояниеОпубликовано - дек 2019

Ключевые слова

  • motor endplate, nicotinic acetylcholine receptor, Na,K-ATPase isoforms, motor activity

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