Выдержка
fragmentation, endplate area, and membrane localization of the α2 isoform of the Na,K–ATPase in the rat
soleus muscle after functional unloading (via the method of hindlimb suspension) for 1–3 days. After unloading
increased endplate fragmentation accompanied by a decrease in the area of individual fragments was
observed; the total area of the endplates did not change. The density of distribution of nicotinic acetylcholine
receptors also remained unaltered; however, the density of the distribution of the α2 isoform of the Na,K–
ATPase significantly decreased. Presumably, these changes resulted from adaptive skeletal muscle remodeling,
which develops not only during chronic disorders, but even in the early stages of motor dysfunction.
| Язык оригинала | английский |
|---|---|
| Страницы (с-по) | 772–776 |
| Журнал | Biophysics (Russian Federation) |
| Том | 64 |
| Номер выпуска | 5 |
| DOI | |
| Состояние | Опубликовано - дек 2019 |
Отпечаток
Ключевые слова
- motor endplate, nicotinic acetylcholine receptor, Na,K-ATPase isoforms, motor activity
Цитировать
}
The Structural and Functional Characteristics of Rat Soleus Endplates under Short-Term Disruption of Motor Activity. / Kravtsova, V. V. ; Saburova, E. A. ; Krivoi, I. I. .
В: Biophysics (Russian Federation), Том 64, № 5, 12.2019, стр. 772–776.Результат исследований: Научные публикации в периодических изданиях › статья
TY - JOUR
T1 - The Structural and Functional Characteristics of Rat Soleus Endplates under Short-Term Disruption of Motor Activity
AU - Kravtsova, V. V.
AU - Saburova, E. A.
AU - Krivoi, I. I.
N1 - Kravtsova, V.V., Saburova, E.A. & Krivoi, I.I. The Structural and Functional Characteristics of Rat Soleus Endplates under Short-Term Disruption of Motor Activity. BIOPHYSICS 64, 772–776 (2019) doi:10.1134/S0006350919050129
PY - 2019/12
Y1 - 2019/12
N2 - In this study we analyzed the distribution of nicotinic acetylcholine receptors, the degree of their fragmentation, endplate area, and membrane localization of the α2 isoform of the Na,K–ATPase in the rat soleus muscle after functional unloading (via the method of hindlimb suspension) for 1–3 days. After unloading increased endplate fragmentation accompanied by a decrease in the area of individual fragments was observed; the total area of the endplates did not change. The density of distribution of nicotinic acetylcholine receptors also remained unaltered; however, the density of the distribution of the α2 isoform of the Na,K– ATPase significantly decreased. Presumably, these changes resulted from adaptive skeletal muscle remodeling, which develops not only during chronic disorders, but even in the early stages of motor dysfunction.
AB - In this study we analyzed the distribution of nicotinic acetylcholine receptors, the degree of their fragmentation, endplate area, and membrane localization of the α2 isoform of the Na,K–ATPase in the rat soleus muscle after functional unloading (via the method of hindlimb suspension) for 1–3 days. After unloading increased endplate fragmentation accompanied by a decrease in the area of individual fragments was observed; the total area of the endplates did not change. The density of distribution of nicotinic acetylcholine receptors also remained unaltered; however, the density of the distribution of the α2 isoform of the Na,K– ATPase significantly decreased. Presumably, these changes resulted from adaptive skeletal muscle remodeling, which develops not only during chronic disorders, but even in the early stages of motor dysfunction.
KW - motor endplate, nicotinic acetylcholine receptor, Na,K-ATPase isoforms, motor activity
KW - motor endplate
KW - nicotinic acetylcholine receptor
KW - Na
KW - K-ATPase isoforms
KW - motor activity
UR - http://www.scopus.com/inward/record.url?scp=85076485835&partnerID=8YFLogxK
U2 - 10.1134/S0006350919050129
DO - 10.1134/S0006350919050129
M3 - Article
VL - 64
SP - 772
EP - 776
JO - Biophysics (Russian Federation)
JF - Biophysics (Russian Federation)
SN - 0006-3509
IS - 5
ER -