The role of osteoprotegerin system/RANKL/rank in pathogenesis of aortic stenosis

O. B. Irtyuga, E. V. Zhiduleva, P. M. Murtazalieva, Yu S. Sibagatullina, L. P. Kruk, V. N. Solntsev, A. A. Shishkova, A. B. Malashicheva, O. M. Moiseeva

Результат исследований: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Аннотация

Aim. To assess the concentrations of osteoprotegerin (OPG) and soluble ligand of the receptor of transcription activator factor kappa-B (sRANKL) in the blood serum of patients with various grade of aortic stenosis (AS) severity. Material and methods. Totally, 247 AS patients studied of various grade: 46 — mild, 53 — moderate and 149 — severe. Of those 132 (53%) with bicuspid aortic valve (BAV) and 115 (47%) with tricuspid (TAV). Controls were 58 patients with no valvular pathology or coronary heart disease. All patients underwent lipid profile measurement, serum C-reactive protein (CRP) and OPG, sRANKL. Results. In all studied groups of AS patients there was increased level of sRANKL in blood serum, comparing to controls (BAV =0,37 [0,32;0,53] pM/L, TAV =0,38 [0,33;0,50] pM/L, controls 0,30 [0,21;0,39] pM/L; р<0,0001). Concentration of OPG was increased only in TAV: 6,99 [5,19;9,90] pM/L; comparing to 5,23 [4,30;7,09] pM/L in BAV (р=0,0008). A hypothesis proposed that OPG concentration increase is compensatory and takes place as a response to the increase of the concentration or due to loss of sensitivity to sRANKL. Conclusion. Development of AS is related to disorders in OPG/RANKL system, and these revealed changes might have significant diagnostic and predictive value, especially in TAV.

Язык оригиналаанглийский
Страницы (с-по)39-43
Число страниц5
ЖурналRussian Journal of Cardiology
Том154
Номер выпуска2
DOI
СостояниеОпубликовано - 1 янв 2018

Предметные области Scopus

  • Кардиология и сердечно-сосудистая медицина

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