The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis

S. V. Lavrushkina, N. L. Ovsyannikova, A. S. Yudina, O. S. Strelkova, O. A. Zhironkina, K. I. Perepelina, A. B. Malashicheva, I. I. Kireev

Результат исследований: Научные публикации в периодических изданияхстатья

Выдержка

The rigid skeleton formed by networks of A- and B-type lamins is responsible for maintaining the nucleus shape. Moreover, the change in the ratio of lamin proteins in its composition, apparently, is a key factor determining mechanical properties of the cell nucleus, in particular plasticity. In this paper, the effect of the component composition of the nuclear lamina on the resistance of cells to mechanical stress and on the cell motility was considered. Expression of mutant forms of lamin A is accompanied by changes in the distance between microdomains of lamins within the nuclear membrane, and its increased bubbling relative to wild-type cells and cells overexpressing lamin A is observed. An increased number of deformed nuclei are noted when exposed to osmotic shock. The assessment of the effect of a change in the molecular composition of the nuclear lamina due to an increase (decrease) in expression of lamin A, as well as the introduction of progerin in an experimental wound model, showed that there are no differences under conditions of unlimited space.

Язык оригиналаанглийский
Страницы (с-по)237-241
ЖурналCell and Tissue Biology
Том13
Номер выпуска3
DOI
СостояниеОпубликовано - 1 мая 2019

Отпечаток

Lamin Type A
Homeostasis
Nuclear Lamina
Lamins
Lamin Type B
Mechanical Stress
Nuclear Envelope
Osmotic Pressure
Cell Nucleus
Skeleton
Cell Movement
Theoretical Models
Wounds and Injuries
Proteins

Предметные области Scopus

  • Клеточная биология

Цитировать

Lavrushkina, S. V., Ovsyannikova, N. L., Yudina, A. S., Strelkova, O. S., Zhironkina, O. A., Perepelina, K. I., ... Kireev, I. I. (2019). The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis. Cell and Tissue Biology, 13(3), 237-241. https://doi.org/10.1134/S1990519X19030064
Lavrushkina, S. V. ; Ovsyannikova, N. L. ; Yudina, A. S. ; Strelkova, O. S. ; Zhironkina, O. A. ; Perepelina, K. I. ; Malashicheva, A. B. ; Kireev, I. I. / The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis. В: Cell and Tissue Biology. 2019 ; Том 13, № 3. стр. 237-241.
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abstract = "The rigid skeleton formed by networks of A- and B-type lamins is responsible for maintaining the nucleus shape. Moreover, the change in the ratio of lamin proteins in its composition, apparently, is a key factor determining mechanical properties of the cell nucleus, in particular plasticity. In this paper, the effect of the component composition of the nuclear lamina on the resistance of cells to mechanical stress and on the cell motility was considered. Expression of mutant forms of lamin A is accompanied by changes in the distance between microdomains of lamins within the nuclear membrane, and its increased bubbling relative to wild-type cells and cells overexpressing lamin A is observed. An increased number of deformed nuclei are noted when exposed to osmotic shock. The assessment of the effect of a change in the molecular composition of the nuclear lamina due to an increase (decrease) in expression of lamin A, as well as the introduction of progerin in an experimental wound model, showed that there are no differences under conditions of unlimited space.",
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Lavrushkina, SV, Ovsyannikova, NL, Yudina, AS, Strelkova, OS, Zhironkina, OA, Perepelina, KI, Malashicheva, AB & Kireev, II 2019, 'The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis', Cell and Tissue Biology, том. 13, № 3, стр. 237-241. https://doi.org/10.1134/S1990519X19030064

The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis. / Lavrushkina, S. V.; Ovsyannikova, N. L.; Yudina, A. S.; Strelkova, O. S.; Zhironkina, O. A.; Perepelina, K. I.; Malashicheva, A. B.; Kireev, I. I.

В: Cell and Tissue Biology, Том 13, № 3, 01.05.2019, стр. 237-241.

Результат исследований: Научные публикации в периодических изданияхстатья

TY - JOUR

T1 - The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis

AU - Lavrushkina, S. V.

AU - Ovsyannikova, N. L.

AU - Yudina, A. S.

AU - Strelkova, O. S.

AU - Zhironkina, O. A.

AU - Perepelina, K. I.

AU - Malashicheva, A. B.

AU - Kireev, I. I.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - The rigid skeleton formed by networks of A- and B-type lamins is responsible for maintaining the nucleus shape. Moreover, the change in the ratio of lamin proteins in its composition, apparently, is a key factor determining mechanical properties of the cell nucleus, in particular plasticity. In this paper, the effect of the component composition of the nuclear lamina on the resistance of cells to mechanical stress and on the cell motility was considered. Expression of mutant forms of lamin A is accompanied by changes in the distance between microdomains of lamins within the nuclear membrane, and its increased bubbling relative to wild-type cells and cells overexpressing lamin A is observed. An increased number of deformed nuclei are noted when exposed to osmotic shock. The assessment of the effect of a change in the molecular composition of the nuclear lamina due to an increase (decrease) in expression of lamin A, as well as the introduction of progerin in an experimental wound model, showed that there are no differences under conditions of unlimited space.

AB - The rigid skeleton formed by networks of A- and B-type lamins is responsible for maintaining the nucleus shape. Moreover, the change in the ratio of lamin proteins in its composition, apparently, is a key factor determining mechanical properties of the cell nucleus, in particular plasticity. In this paper, the effect of the component composition of the nuclear lamina on the resistance of cells to mechanical stress and on the cell motility was considered. Expression of mutant forms of lamin A is accompanied by changes in the distance between microdomains of lamins within the nuclear membrane, and its increased bubbling relative to wild-type cells and cells overexpressing lamin A is observed. An increased number of deformed nuclei are noted when exposed to osmotic shock. The assessment of the effect of a change in the molecular composition of the nuclear lamina due to an increase (decrease) in expression of lamin A, as well as the introduction of progerin in an experimental wound model, showed that there are no differences under conditions of unlimited space.

KW - cell motility

KW - LINC complex

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VL - 13

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EP - 241

JO - Cell and Tissue Biology

JF - Cell and Tissue Biology

SN - 1990-519X

IS - 3

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Lavrushkina SV, Ovsyannikova NL, Yudina AS, Strelkova OS, Zhironkina OA, Perepelina KI и соавт. The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis. Cell and Tissue Biology. 2019 Май 1;13(3):237-241. https://doi.org/10.1134/S1990519X19030064