The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models

Konstantin A. Demin, Anton M. Lakstygal, Polina A. Alekseeva, Maxim Sysoev, Murilo S. de Abreu, Erik T. Alpyshov, Nazar Serikuly, Dong Mei Wang, Meng Yao Wang, Zhi Chong Tang, Dong Ni Yan, Tatyana V. Strekalova, Andrey D. Volgin, Tamara G. Amstislavskaya, Jia Jia Wang, Cai Song, Allan V. Kalueff

Результат исследований: Научные публикации в периодических изданияхОбзорная статьярецензирование

8 Цитирования (Scopus)

Аннотация

Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.

Язык оригиналаанглийский
Страницы (с-по)44-55
Число страниц12
ЖурналAquatic Toxicology
Том210
DOI
СостояниеОпубликовано - 1 мая 2019

Предметные области Scopus

  • Акванаука
  • Здоровье, токсикология и мутагенез

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