The pathogenetic role of β-cell mitochondria in type 2 diabetes

Malin Fex, Lisa M. Nicholas, Neelanjan Vishnu, Anya Medina, Vladimir V. Sharoyko, David G. Nicholls, Peter Spégel, Hindrik Mulder

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

10 Цитирования (Scopus)

Выдержка

Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mitochondria is a rare condition but causes a type 2 diabetes-like syndrome owing to β-cell failure. Here, we describe novel advances in research on mitochondrial dysfunction in the β-cell in type 2 diabetes, with a focus on human studies. Relevant studies in animal and cell models of the disease are described. Transcriptional and translational regulation in mitochondria are particularly emphasized. The role of metabolic enzymes and pathways and their impact on β-cell function in type 2 diabetes pathophysiology are discussed. The role of genetic variation in mitochondrial function leading to type 2 diabetes is highlighted. We argue that alterations in mitochondria may be a culprit in the pathogenetic processes culminating in type 2 diabetes.

Язык оригиналаанглийский
Страницы (с-по)R145-R149
ЖурналJournal of Endocrinology
Том236
Номер выпуска3
DOI
СостояниеОпубликовано - 1 янв 2018

Отпечаток

Type 2 Diabetes Mellitus
Mitochondria
Insulin
Animal Disease Models
Metabolic Networks and Pathways
Hyperglycemia
Glucose
Enzymes
Research

Предметные области Scopus

  • Эндокринология, диабет и метаболизм
  • Эндокринология

Цитировать

Fex, M., Nicholas, L. M., Vishnu, N., Medina, A., Sharoyko, V. V., Nicholls, D. G., ... Mulder, H. (2018). The pathogenetic role of β-cell mitochondria in type 2 diabetes. Journal of Endocrinology, 236(3), R145-R149. https://doi.org/10.1530/JOE-17-0367
Fex, Malin ; Nicholas, Lisa M. ; Vishnu, Neelanjan ; Medina, Anya ; Sharoyko, Vladimir V. ; Nicholls, David G. ; Spégel, Peter ; Mulder, Hindrik. / The pathogenetic role of β-cell mitochondria in type 2 diabetes. В: Journal of Endocrinology. 2018 ; Том 236, № 3. стр. R145-R149.
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abstract = "Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mitochondria is a rare condition but causes a type 2 diabetes-like syndrome owing to β-cell failure. Here, we describe novel advances in research on mitochondrial dysfunction in the β-cell in type 2 diabetes, with a focus on human studies. Relevant studies in animal and cell models of the disease are described. Transcriptional and translational regulation in mitochondria are particularly emphasized. The role of metabolic enzymes and pathways and their impact on β-cell function in type 2 diabetes pathophysiology are discussed. The role of genetic variation in mitochondrial function leading to type 2 diabetes is highlighted. We argue that alterations in mitochondria may be a culprit in the pathogenetic processes culminating in type 2 diabetes.",
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Fex, M, Nicholas, LM, Vishnu, N, Medina, A, Sharoyko, VV, Nicholls, DG, Spégel, P & Mulder, H 2018, 'The pathogenetic role of β-cell mitochondria in type 2 diabetes', Journal of Endocrinology, том. 236, № 3, стр. R145-R149. https://doi.org/10.1530/JOE-17-0367

The pathogenetic role of β-cell mitochondria in type 2 diabetes. / Fex, Malin; Nicholas, Lisa M.; Vishnu, Neelanjan; Medina, Anya; Sharoyko, Vladimir V.; Nicholls, David G.; Spégel, Peter; Mulder, Hindrik.

В: Journal of Endocrinology, Том 236, № 3, 01.01.2018, стр. R145-R149.

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

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AU - Fex, Malin

AU - Nicholas, Lisa M.

AU - Vishnu, Neelanjan

AU - Medina, Anya

AU - Sharoyko, Vladimir V.

AU - Nicholls, David G.

AU - Spégel, Peter

AU - Mulder, Hindrik

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mitochondria is a rare condition but causes a type 2 diabetes-like syndrome owing to β-cell failure. Here, we describe novel advances in research on mitochondrial dysfunction in the β-cell in type 2 diabetes, with a focus on human studies. Relevant studies in animal and cell models of the disease are described. Transcriptional and translational regulation in mitochondria are particularly emphasized. The role of metabolic enzymes and pathways and their impact on β-cell function in type 2 diabetes pathophysiology are discussed. The role of genetic variation in mitochondrial function leading to type 2 diabetes is highlighted. We argue that alterations in mitochondria may be a culprit in the pathogenetic processes culminating in type 2 diabetes.

AB - Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mitochondria is a rare condition but causes a type 2 diabetes-like syndrome owing to β-cell failure. Here, we describe novel advances in research on mitochondrial dysfunction in the β-cell in type 2 diabetes, with a focus on human studies. Relevant studies in animal and cell models of the disease are described. Transcriptional and translational regulation in mitochondria are particularly emphasized. The role of metabolic enzymes and pathways and their impact on β-cell function in type 2 diabetes pathophysiology are discussed. The role of genetic variation in mitochondrial function leading to type 2 diabetes is highlighted. We argue that alterations in mitochondria may be a culprit in the pathogenetic processes culminating in type 2 diabetes.

KW - Coupling signal

KW - Genetic variation

KW - Mitochondrial transcription

KW - Oxidative phosphorylation

KW - TCA cycle

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Fex M, Nicholas LM, Vishnu N, Medina A, Sharoyko VV, Nicholls DG и соавт. The pathogenetic role of β-cell mitochondria in type 2 diabetes. Journal of Endocrinology. 2018 Янв. 1;236(3):R145-R149. https://doi.org/10.1530/JOE-17-0367