The Notch pathway: a novel therapeutic target for cardiovascular diseases?

Giorgio Aquila, Aleksandra Kostina, Francesco Vieceli Dalla Sega, Eugeniy Shlyakhto, Anna Kostareva, Luisa Marracino, Roberto Ferrari, Paola Rizzo, Anna Malaschicheva

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

4 Цитирования (Scopus)

Аннотация

Introduction: The Notch pathway is involved in determining cell fate during development and postnatally in continuously renewing tissues, such as the endothelium, the epithelium, and in the stem cells pool. The dysregulation of the Notch pathway is one of the causes of limited response, or resistance, to available cancer treatments and novel therapeutic strategies based on Notch inhibition are being investigated in preclinical and clinical studies in oncology. A large body of evidence now shows that the dysregulation of the Notch pathway is also involved in the pathophysiology of cardiovascular diseases (CVDs). Areas covered: This review discusses the molecular mechanisms involving Notch which underlie heart failure, aortic valve calcification, and aortic aneurysm. Expert opinion: Despite the existence of preventive, pharmacological and surgical interventions approaches, CVDs are the first causes of mortality worldwide. The Notch pathway is becoming increasingly recognized as being involved in heart failure, aortic aneurysm and aortic valve calcification, which are among the most common global causes of mortality due to CVDs. As already shown in cancer, the dissection of the biological processes and molecular mechanisms involving Notch should pave the way for new strategies to prevent and cure these diseases.

Язык оригиналаанглийский
Страницы (с-по)695-710
ЖурналExpert Opinion on Therapeutic Targets
Том23
Номер выпуска8
Ранняя дата в режиме онлайн14 июл 2019
DOI
СостояниеОпубликовано - 3 авг 2019

Предметные области Scopus

  • Молекулярная медицина
  • Фармакология
  • Поиск новых лекарств
  • Клиническая биохимия

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  • Цитировать

    Aquila, G., Kostina, A., Vieceli Dalla Sega, F., Shlyakhto, E., Kostareva, A., Marracino, L., Ferrari, R., Rizzo, P., & Malaschicheva, A. (2019). The Notch pathway: a novel therapeutic target for cardiovascular diseases? Expert Opinion on Therapeutic Targets, 23(8), 695-710. https://doi.org/10.1080/14728222.2019.1641198