THE EFFECTS OF EPIPHYSEAL PEPTIDES ON THE RELEASE OF IMMUNOGLOBULINS IN PEYER’S PATCHES IN RATS IN VITRO

O.A. Zimina, R.I. Kovalenko, A.D. Nozdrachev

Результат исследований: Научные публикации в периодических изданияхстатья

Аннотация

The effects of epiphyseal peptides (1 μg/ml) on the release of immunoglobulins into the incubation medium by isolated Peyer’s patches from non-immunized mice and mice immunized orally against ovalbumin were studied during 40-min incubations. The possibility that epiphyseal peptides act on adrenoreceptors of cells in secondary lymphoid organs in the small intestine was assessed using α- and β-adrenoreceptor blockers, i.e., phentolamine HCl (0.02 mg/ml) and anaprilin (0.06 mg/ml) respectively. Basal levels of secretory activity in control Peyer’s patches from immunized rats were 2.4 times (p <0.01) greater than for the lymphoid organs of non-immunized animals. The effects of epiphyseal peptides on the secretory activity of antibody-forming cells depended on the functional state of Peyer’s patches. Application of epiphyseal peptides led to a 35% increase (p <0.05) in the release of immunoglobulins from Peyer’s patches in non-immunized rats and a 25% decrease (p <0.05) in the release of antibody into the incub
Язык оригиналаанглийский
Страницы (с-по)893-897
ЖурналNeuroscience and Behavioral Physiology
Номер выпуска9
СостояниеОпубликовано - 2003
Опубликовано для внешнего пользованияДа

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