The effect of glutoxim on Na+ transport in frog skin: the role of cytoskeleton

A. V. Melnitskaya, Z. I. Krutetskaya, O. E. Lebedev, S. N. Butov, N. I. Krutetskaya, V. G. Antonov

Результат исследований: Научные публикации в периодических изданияхстатьярецензирование

1 Цитирования (Scopus)

Аннотация

Using voltage-clamp technique, the possible role of the cytoskeleton in the effect of pharmacological analogue of oxidized glutathione (GSSG), drug glutoxim, on Na+ transport in the frog Rana temporaria skin was investigated. It was shown for the first time that preincubation of the skin with the microtubular disrupter nocodazole, actin filament disrupter cytochalasin D or protein phosphatase PP1/PP2A inhibitor calyculin A, significantly decrease the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of microtubules and microfilaments in the regulatory effect of glutoxim on Na+ transport in frog skin and that reorganization of actin filaments or microtubules leads to inhibition of stimulatory effect of glutoxim on Na+ transport in frog skin epithelia.
Язык оригиналаанглийский
Страницы (с-по)248-253
ЖурналCell and Tissue Biology
Том6
Номер выпуска3
DOI
СостояниеОпубликовано - 2012

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