The dopamine transporter expression level differentially affects responses to cocaine and amphetamine.

B Cagniard, TD Sotnikova, RR Gainetdinov, X. Zhuang

Результат исследований: Научные публикации в периодических изданияхстатья

16 Цитирования (Scopus)

Аннотация

Although both cocaine and amphetamine mainly target the dopamine transporter (DAT) and cause psychomotor effects, they have very different mechanisms of actions. The authors examined whether responses to cocaine and amphetamine were affected differentially by changes in DAT expression levels using transgenic mice with different DAT expression levels. In the constitutive DAT knockdown mice, reduced DAT expression enhanced cocaine's locomotor stimulatory effects and at the same time diminished amphetamine's locomotor stimulatory effects. Similar effects were observed in the inducible DAT knockdown mice, ruling out the contribution of developmental compensations in DAT knockdown mice. Extracellular dopamine levels in response to psychostimulants were assessed by in vivo microdialysis. Whereas amphetamine-induced increase in extracellular dopamine was drastically diminished in constitutive DAT knockdown mice, cocaine-induced increase in extracellular dopamine had a faster onset in knockdown mice compared with wil
Язык оригиналане определен
ЖурналJournal of Neurogenetics
СостояниеОпубликовано - 2014
Опубликовано для внешнего пользованияДа

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