Testing anxiolytic drugs in the C57BL/6J mouse strain

Allan V. Kalueff, Michael Nguyen

Результат исследований: Научные публикации в периодических изданияхписьмо/краткое сообщение

5 Цитирования (Scopus)

Выдержка

C57BL/6J mice are one of the most commonly used mouse strains in biobehavioral and psychopharmacological research. Prone to variance due to multiple environmental factors, animal neurophenotyping studies rely on using proper experimental protocols, study designs and well-established models and tests. Choosing the dose range for anxiolytic or anxiogenic drugs is key for obtaining valid testing results and correct data interpretation. Here we emphasize the importance of accurate dose selection in rodent anxiety paradigms for concluding whether the mouse strain used is "sensitive" and therefore appropriate for studying anxiety in selected behavioral tests. We also provide further argument in support of using the C57BL/6J mouse strain for testing anxiolytic and anxiogenic compounds.

Язык оригиналаанглийский
Страницы (с-по)205-207
Число страниц3
ЖурналJournal of Pharmacological and Toxicological Methods
Том69
Номер выпуска2
DOI
СостояниеОпубликовано - 2014
Опубликовано для внешнего пользованияДа

Отпечаток

Anti-Anxiety Agents
Inbred C57BL Mouse
Anxiety
Testing
Pharmaceutical Preparations
Rodentia
Animals
Research
Behavior Rating Scale

Предметные области Scopus

  • Токсикология
  • Фармакология

Цитировать

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Testing anxiolytic drugs in the C57BL/6J mouse strain. / Kalueff, Allan V.; Nguyen, Michael.

В: Journal of Pharmacological and Toxicological Methods, Том 69, № 2, 2014, стр. 205-207.

Результат исследований: Научные публикации в периодических изданияхписьмо/краткое сообщение

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