Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies

Anastasia M Konstantinova, Liubov Kyrpychova, Jana Nemcova, Monica Sedivcova, Michele Bisceglia, Heinz Kutzner, Michal Zamecnik, Eva Sehnalkova, Michal Pavlovsky, Kamila Zateckova, Sergej Shvernik, Zuzana Spurkova, Michal Michal, Katrin Kerl, Dmitry V Kazakov

Результат исследований: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Выдержка

Syringocystadenoma papilliferum (SCAP) is a benign tumor most commonly located on the head and neck area often associated with nevus sebaceus. In its usual location, the human papillomavirus (HPV) DNA and mutations in the RAS/mitogen-activated protein kinase signaling pathway have been detected in SCAP. We studied 16 cases of SCAP in the anogenital areas and buttock where this neoplasm is rare and attempted to find out whether SCAP in these sites have different histopathological and molecular biological features. It seems that there is no significant difference between the morphology of anogenital SCAP and SCAP in other locations. Several tumors in our cohort demonstrated features resembling those seen in warts, but HPV DNA was not found in these lesions. On the contrary, we identified DNA of HPV high-risk types in some tumors without HPV-related morphology. Our study confirms the role of HRAS and BRAF V600 mutations in the pathogenesis of SCAP, including SCAP in the anogenital areas and buttock.

Язык оригиналаанглийский
Страницы (с-по)281-285
Число страниц5
ЖурналAmerican Journal of Dermatopathology
Том41
Номер выпуска4
DOI
СостояниеОпубликовано - 2019

Отпечаток

Buttocks
Mutation
DNA
Neoplasms
Warts
Nevus
Mitogen-Activated Protein Kinases
Neck
Head

Цитировать

Konstantinova, Anastasia M ; Kyrpychova, Liubov ; Nemcova, Jana ; Sedivcova, Monica ; Bisceglia, Michele ; Kutzner, Heinz ; Zamecnik, Michal ; Sehnalkova, Eva ; Pavlovsky, Michal ; Zateckova, Kamila ; Shvernik, Sergej ; Spurkova, Zuzana ; Michal, Michal ; Kerl, Katrin ; Kazakov, Dmitry V. / Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks : A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies. В: American Journal of Dermatopathology. 2019 ; Том 41, № 4. стр. 281-285.
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abstract = "Syringocystadenoma papilliferum (SCAP) is a benign tumor most commonly located on the head and neck area often associated with nevus sebaceus. In its usual location, the human papillomavirus (HPV) DNA and mutations in the RAS/mitogen-activated protein kinase signaling pathway have been detected in SCAP. We studied 16 cases of SCAP in the anogenital areas and buttock where this neoplasm is rare and attempted to find out whether SCAP in these sites have different histopathological and molecular biological features. It seems that there is no significant difference between the morphology of anogenital SCAP and SCAP in other locations. Several tumors in our cohort demonstrated features resembling those seen in warts, but HPV DNA was not found in these lesions. On the contrary, we identified DNA of HPV high-risk types in some tumors without HPV-related morphology. Our study confirms the role of HRAS and BRAF V600 mutations in the pathogenesis of SCAP, including SCAP in the anogenital areas and buttock.",
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author = "Konstantinova, {Anastasia M} and Liubov Kyrpychova and Jana Nemcova and Monica Sedivcova and Michele Bisceglia and Heinz Kutzner and Michal Zamecnik and Eva Sehnalkova and Michal Pavlovsky and Kamila Zateckova and Sergej Shvernik and Zuzana Spurkova and Michal Michal and Katrin Kerl and Kazakov, {Dmitry V}",
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Konstantinova, AM, Kyrpychova, L, Nemcova, J, Sedivcova, M, Bisceglia, M, Kutzner, H, Zamecnik, M, Sehnalkova, E, Pavlovsky, M, Zateckova, K, Shvernik, S, Spurkova, Z, Michal, M, Kerl, K & Kazakov, DV 2019, 'Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies', American Journal of Dermatopathology, том. 41, № 4, стр. 281-285. https://doi.org/10.1097/DAD.0000000000001285

Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks : A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies. / Konstantinova, Anastasia M; Kyrpychova, Liubov; Nemcova, Jana; Sedivcova, Monica; Bisceglia, Michele; Kutzner, Heinz; Zamecnik, Michal; Sehnalkova, Eva; Pavlovsky, Michal; Zateckova, Kamila; Shvernik, Sergej; Spurkova, Zuzana; Michal, Michal; Kerl, Katrin; Kazakov, Dmitry V.

В: American Journal of Dermatopathology, Том 41, № 4, 2019, стр. 281-285.

Результат исследований: Научные публикации в периодических изданияхстатья

TY - JOUR

T1 - Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks

T2 - A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies

AU - Konstantinova, Anastasia M

AU - Kyrpychova, Liubov

AU - Nemcova, Jana

AU - Sedivcova, Monica

AU - Bisceglia, Michele

AU - Kutzner, Heinz

AU - Zamecnik, Michal

AU - Sehnalkova, Eva

AU - Pavlovsky, Michal

AU - Zateckova, Kamila

AU - Shvernik, Sergej

AU - Spurkova, Zuzana

AU - Michal, Michal

AU - Kerl, Katrin

AU - Kazakov, Dmitry V

PY - 2019

Y1 - 2019

N2 - Syringocystadenoma papilliferum (SCAP) is a benign tumor most commonly located on the head and neck area often associated with nevus sebaceus. In its usual location, the human papillomavirus (HPV) DNA and mutations in the RAS/mitogen-activated protein kinase signaling pathway have been detected in SCAP. We studied 16 cases of SCAP in the anogenital areas and buttock where this neoplasm is rare and attempted to find out whether SCAP in these sites have different histopathological and molecular biological features. It seems that there is no significant difference between the morphology of anogenital SCAP and SCAP in other locations. Several tumors in our cohort demonstrated features resembling those seen in warts, but HPV DNA was not found in these lesions. On the contrary, we identified DNA of HPV high-risk types in some tumors without HPV-related morphology. Our study confirms the role of HRAS and BRAF V600 mutations in the pathogenesis of SCAP, including SCAP in the anogenital areas and buttock.

AB - Syringocystadenoma papilliferum (SCAP) is a benign tumor most commonly located on the head and neck area often associated with nevus sebaceus. In its usual location, the human papillomavirus (HPV) DNA and mutations in the RAS/mitogen-activated protein kinase signaling pathway have been detected in SCAP. We studied 16 cases of SCAP in the anogenital areas and buttock where this neoplasm is rare and attempted to find out whether SCAP in these sites have different histopathological and molecular biological features. It seems that there is no significant difference between the morphology of anogenital SCAP and SCAP in other locations. Several tumors in our cohort demonstrated features resembling those seen in warts, but HPV DNA was not found in these lesions. On the contrary, we identified DNA of HPV high-risk types in some tumors without HPV-related morphology. Our study confirms the role of HRAS and BRAF V600 mutations in the pathogenesis of SCAP, including SCAP in the anogenital areas and buttock.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anal Canal/pathology

KW - Buttocks/pathology

KW - Female

KW - Genital Neoplasms, Female/genetics

KW - Genital Neoplasms, Male/genetics

KW - Humans

KW - Male

KW - Middle Aged

KW - Mutation

KW - Papillomaviridae

KW - Papillomavirus Infections/epidemiology

KW - Proto-Oncogene Proteins B-raf/genetics

KW - Proto-Oncogene Proteins p21(ras)/genetics

KW - Sweat Gland Neoplasms/genetics

KW - Tubular Sweat Gland Adenomas/genetics

KW - Young Adult

U2 - 10.1097/DAD.0000000000001285

DO - 10.1097/DAD.0000000000001285

M3 - Article

C2 - 30398985

VL - 41

SP - 281

EP - 285

JO - American Journal of Dermatopathology

JF - American Journal of Dermatopathology

SN - 0193-1091

IS - 4

ER -