Synthesis of 1,2,4-Oxadiazoles by Tandem Reaction of Nitroalkenes with Arenes and Nitriles in the Superacid TfOH

Результат исследований: Научные публикации в периодических изданияхстатья

Выдержка

The tandem reaction of nitroalkenes with arenes and nitriles in the superacid CF3SO3H (TfOH) results in the formation of 1,2,4-oxadiazole derivatives in yields up to 96%. This reaction proceeds via the consequent interaction of arenes and nitriles, as nucleophiles, with intermediate cationic species derived by the protonation of nitroalkenes in TfOH. This is novel and general synthesis of 1,2,4-oxadiazoles, which are very important compounds for medicinal chemistry.

Язык оригиналаанглийский
Страницы (с-по)7495-7500
Число страниц6
ЖурналJournal of Organic Chemistry
Том84
Номер выпуска11
DOI
СостояниеОпубликовано - 7 июн 2019

Отпечаток

Oxadiazoles
Nitriles
Nucleophiles
Protonation
Derivatives
Pharmaceutical Chemistry

Предметные области Scopus

  • Органическая химия

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title = "Synthesis of 1,2,4-Oxadiazoles by Tandem Reaction of Nitroalkenes with Arenes and Nitriles in the Superacid TfOH",
abstract = "The tandem reaction of nitroalkenes with arenes and nitriles in the superacid CF3SO3H (TfOH) results in the formation of 1,2,4-oxadiazole derivatives in yields up to 96{\%}. This reaction proceeds via the consequent interaction of arenes and nitriles, as nucleophiles, with intermediate cationic species derived by the protonation of nitroalkenes in TfOH. This is novel and general synthesis of 1,2,4-oxadiazoles, which are very important compounds for medicinal chemistry.",
author = "Golushko, {Andrei A.} and Khoroshilova, {Olesya V.} and Vasilyev, {Aleksander V.}",
year = "2019",
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journal = "Journal of Organic Chemistry",
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Synthesis of 1,2,4-Oxadiazoles by Tandem Reaction of Nitroalkenes with Arenes and Nitriles in the Superacid TfOH. / Golushko, Andrei A.; Khoroshilova, Olesya V.; Vasilyev, Aleksander V.

В: Journal of Organic Chemistry, Том 84, № 11, 07.06.2019, стр. 7495-7500.

Результат исследований: Научные публикации в периодических изданияхстатья

TY - JOUR

T1 - Synthesis of 1,2,4-Oxadiazoles by Tandem Reaction of Nitroalkenes with Arenes and Nitriles in the Superacid TfOH

AU - Golushko, Andrei A.

AU - Khoroshilova, Olesya V.

AU - Vasilyev, Aleksander V.

PY - 2019/6/7

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N2 - The tandem reaction of nitroalkenes with arenes and nitriles in the superacid CF3SO3H (TfOH) results in the formation of 1,2,4-oxadiazole derivatives in yields up to 96%. This reaction proceeds via the consequent interaction of arenes and nitriles, as nucleophiles, with intermediate cationic species derived by the protonation of nitroalkenes in TfOH. This is novel and general synthesis of 1,2,4-oxadiazoles, which are very important compounds for medicinal chemistry.

AB - The tandem reaction of nitroalkenes with arenes and nitriles in the superacid CF3SO3H (TfOH) results in the formation of 1,2,4-oxadiazole derivatives in yields up to 96%. This reaction proceeds via the consequent interaction of arenes and nitriles, as nucleophiles, with intermediate cationic species derived by the protonation of nitroalkenes in TfOH. This is novel and general synthesis of 1,2,4-oxadiazoles, which are very important compounds for medicinal chemistry.

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