Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m

Результат исследований: Научные публикации в периодических изданияхстатья

3 Цитирования (Scopus)

Выдержка

The procedure of the directed synthesis of N‐vinylpyrrolidone‐N‐vinylformamide (VP‐VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium‐113m were developed. The metal‐copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high‐performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium‐113m were optimized. It was shown that the VP‐VFA‐IDA copolymer firmly binds indium‐113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP‐VFA‐IDA‐In conjugates were found to be unstable in histidine challenge reaction.
Язык оригиналаанглийский
Страницы (с-по)302-311
ЖурналJournal of Labelled Compounds and Radiopharmaceuticals
Том60
Номер выпуска6
DOI
СостояниеОпубликовано - 2017

Цитировать

@article{4971a822060640c5b1770f2fad085e81,
title = "Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m",
abstract = "The procedure of the directed synthesis of N‐vinylpyrrolidone‐N‐vinylformamide (VP‐VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium‐113m were developed. The metal‐copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high‐performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium‐113m were optimized. It was shown that the VP‐VFA‐IDA copolymer firmly binds indium‐113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP‐VFA‐IDA‐In conjugates were found to be unstable in histidine challenge reaction.",
author = "Тюпина, {Маргарита Юрьевна} and Мирославов, {Александр Евгеньевич}",
year = "2017",
doi = "10.1002/jlcr.3503",
language = "English",
volume = "60",
pages = "302--311",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "Wiley-Blackwell",
number = "6",

}

Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m. / Тюпина, Маргарита Юрьевна; Мирославов, Александр Евгеньевич.

В: Journal of Labelled Compounds and Radiopharmaceuticals, Том 60, № 6, 2017, стр. 302-311.

Результат исследований: Научные публикации в периодических изданияхстатья

TY - JOUR

T1 - Study of N-vinylpyrrolidone-N-vinylformamide copolymers labelled with indium-113m

AU - Тюпина, Маргарита Юрьевна

AU - Мирославов, Александр Евгеньевич

PY - 2017

Y1 - 2017

N2 - The procedure of the directed synthesis of N‐vinylpyrrolidone‐N‐vinylformamide (VP‐VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium‐113m were developed. The metal‐copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high‐performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium‐113m were optimized. It was shown that the VP‐VFA‐IDA copolymer firmly binds indium‐113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP‐VFA‐IDA‐In conjugates were found to be unstable in histidine challenge reaction.

AB - The procedure of the directed synthesis of N‐vinylpyrrolidone‐N‐vinylformamide (VP‐VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium‐113m were developed. The metal‐copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high‐performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium‐113m were optimized. It was shown that the VP‐VFA‐IDA copolymer firmly binds indium‐113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP‐VFA‐IDA‐In conjugates were found to be unstable in histidine challenge reaction.

U2 - 10.1002/jlcr.3503

DO - 10.1002/jlcr.3503

M3 - Article

VL - 60

SP - 302

EP - 311

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 6

ER -