Stagonolides J and K and Stagochromene A, Two New Natural Substituted Nonenolides and a New Disubstituted Chromene-4,5-dione Isolated from Stagonospora cirsii S-47 Proposed for the Biocontrol of Sonchus arvensis

Anna Dalinova, Vsevolod Dubovik, Leonid Chisty, Dmitriy Kochura, Alexander Ivanov, Sergey Smirnov, Maria Petrova, Andrey Zolotarev, Antonio Evidente, Alexander Berestetskiy

Результат исследований: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Аннотация

Two new natural 10-membered macrolides (1, 2) and one chromene-4,5-dione derivative (3), named stagonolides J and K and stagochromene A, respectively, were isolated from the phytopathogenic fungus Stagonospora cirsii S-47, together with two known compounds, stagonolide A (4) and herbarumin I (5). Stagonolides J and K and stagochromene A were characterized as (5E,7R*,8S*,9R*)-7,8-dihydroxy-9-propyl-5-nonen-9-olide, (5E,7R,9S)-7-hydroxy-9-propyl-5-nonen-9-olide, and (2R*,3R*)-3-hydroxy-2-propyltetrahydro-2H-chromene-4,5(3H,4aH)-dione, respectively, by spectroscopic (mostly by NMR and ESIMS) data. Compounds 1-5 showed different rates of phytotoxic activity on punctured leaf discs of Sonchus arvensis. The antimicrobial, cytotoxic, and antiprotozoal activity of isolated compounds was also evaluated. Based on our data, stagonolide K and herbarumin I can be proposed as a potential scaffold for the development of a new natural herbicide and estimated as possible selection/quality markers of a bioherbicide based on S. cirsii, while stagonolide A can be considered as a mycotoxin.

Язык оригиналаанглийский
Страницы (с-по)13040-13050
ЖурналJournal of Agricultural and Food Chemistry
Том67
Номер выпуска47
Ранняя дата в режиме онлайн31 окт 2019
DOI
СостояниеОпубликовано - 27 ноя 2019

Предметные области Scopus

  • Земледелие и биологические науки (все)
  • Химия (все)

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