Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People

Standard

Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People. / Kovaleva, A. V. ; Astratenkova, I. V. ; Golovanova, N. E. ; Orlova, O. G. ; Rybalchenko, O. V. .

в: ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА, Том 14, № 2, 2019, стр. 141-146.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{dfebafd5e1704e3dbda6f5ef4228b284,

title = "Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People",

abstract = "Arterial hypertension is one of the most common cardiovascular diseases and one of the main causes of mortality and disability of population. Opportunity to predict emergence of arterial hypertension and to take preventive measures in pre-nosological diagnostics of disease arouse research interest in this issue. Possibility to predict progression of arterial hypertension based on polymorphic variants of AGT gene (C521T, rs4762) identification, which encodes angiotensinogen protein in combination with polymorphic variants of CAT (-262C/T, rs1001179), encoding catalase, and polymorphic variants of SOD2 (C47T, rs4880), encoding mitochondrial superoxide dismutase, are discussed in this article. Decrease of antioxidant enzymes (catalase and superoxide dismutase) activity leads to accumulation of reactive oxygen species in cells. They may activate NF-kB transcription factor, which increases expression of individual genes involved insodium homeostasis and in blood pressure control, including angiotensinogen...",

keywords = "arterial hypertension, genetic polymorphism, angiotensinogen, superoxide dismutase, catalase, arterial hypertension, GENETIC POLYMORPHISMS, angiotensinogen, Superoxide dismutase, catalase",

author = "Kovaleva, {A. V.} and Astratenkova, {I. V.} and Golovanova, {N. E.} and Orlova, {O. G.} and Rybalchenko, {O. V.}",

note = "Kovaleva A. V., Astratenkova I. V., Golovanova N. E., Orlova O. G., Rybalchenko O. V. Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People. Vestnik of Saint Petersburg University. Medicine, 2019, vol. 14, issue 2, pp. 141–146. https://doi.org/10.21638/spbu11.2019.206",

year = "2019",

language = "English",

volume = "14",

pages = "141--146",

journal = " ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА",

issn = "1818-2909",

publisher = "Издательство Санкт-Петербургского университета",

number = "2",

}

RIS

TY - JOUR

T1 - Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People

AU - Kovaleva, A. V.

AU - Astratenkova, I. V.

AU - Golovanova, N. E.

AU - Orlova, O. G.

AU - Rybalchenko, O. V.

N1 - Kovaleva A. V., Astratenkova I. V., Golovanova N. E., Orlova O. G., Rybalchenko O. V. Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People. Vestnik of Saint Petersburg University. Medicine, 2019, vol. 14, issue 2, pp. 141–146. https://doi.org/10.21638/spbu11.2019.206

PY - 2019

Y1 - 2019

N2 - Arterial hypertension is one of the most common cardiovascular diseases and one of the main causes of mortality and disability of population. Opportunity to predict emergence of arterial hypertension and to take preventive measures in pre-nosological diagnostics of disease arouse research interest in this issue. Possibility to predict progression of arterial hypertension based on polymorphic variants of AGT gene (C521T, rs4762) identification, which encodes angiotensinogen protein in combination with polymorphic variants of CAT (-262C/T, rs1001179), encoding catalase, and polymorphic variants of SOD2 (C47T, rs4880), encoding mitochondrial superoxide dismutase, are discussed in this article. Decrease of antioxidant enzymes (catalase and superoxide dismutase) activity leads to accumulation of reactive oxygen species in cells. They may activate NF-kB transcription factor, which increases expression of individual genes involved insodium homeostasis and in blood pressure control, including angiotensinogen...

AB - Arterial hypertension is one of the most common cardiovascular diseases and one of the main causes of mortality and disability of population. Opportunity to predict emergence of arterial hypertension and to take preventive measures in pre-nosological diagnostics of disease arouse research interest in this issue. Possibility to predict progression of arterial hypertension based on polymorphic variants of AGT gene (C521T, rs4762) identification, which encodes angiotensinogen protein in combination with polymorphic variants of CAT (-262C/T, rs1001179), encoding catalase, and polymorphic variants of SOD2 (C47T, rs4880), encoding mitochondrial superoxide dismutase, are discussed in this article. Decrease of antioxidant enzymes (catalase and superoxide dismutase) activity leads to accumulation of reactive oxygen species in cells. They may activate NF-kB transcription factor, which increases expression of individual genes involved insodium homeostasis and in blood pressure control, including angiotensinogen...

KW - arterial hypertension

KW - genetic polymorphism

KW - angiotensinogen

KW - superoxide dismutase

KW - catalase

KW - arterial hypertension

KW - GENETIC POLYMORPHISMS

KW - angiotensinogen

KW - Superoxide dismutase

KW - catalase

UR - https://medicine-journal.spbu.ru/article/view/5012/4879

M3 - Article

VL - 14

SP - 141

EP - 146

JO - ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА

JF - ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА

SN - 1818-2909

IS - 2

ER -

ID: 49337133