Sigma-1 receptor antagonists haloperidol and chlorpromazine modulate the effect of glutoxim on Na+ transport in frog skin

Результат исследований: Научные публикации в периодических изданияхстатья

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Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+
transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first
time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine
attenuates the stimulatory effect of glutoxim on the Na+ transport. The results suggest the possible
involvement of the sigma-1 receptors in the regulation of Na+ transport in frog skin epithelium by glutoxim.
DOI: 10.1134/S1607672919010186
Язык оригиналаанглийский
Страницы (с-по)63-65
Число страниц3
ЖурналDoklady Biochemistry and Biophysics
Том484
Номер выпуска1
DOI
СостояниеОпубликовано - 1 мая 2019

Предметные области Scopus

  • Биохимия, генетика и молекулярная биология (все)

Ключевые слова

  • sigma-1 receptor, immunomodulatory drug glutoxim, neuroleptics, Na+ transport,

Цитировать

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title = "Sigma-1 receptor antagonists haloperidol and chlorpromazine modulate the effect of glutoxim on Na+ transport in frog skin",
abstract = "Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the firsttime that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazineattenuates the stimulatory effect of glutoxim on the Na+ transport. The results suggest the possibleinvolvement of the sigma-1 receptors in the regulation of Na+ transport in frog skin epithelium by glutoxim.DOI: 10.1134/S1607672919010186",
keywords = "sigma-1 receptor, immunomodulatory drug glutoxim, neuroleptics, Na+ transport,",
author = "{A. V. Melnitskaya} and {Z. I. Krutetskaya} and {V. G. Antonov} and {A. D. Nozdrachev}",
year = "2019",
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day = "1",
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number = "1",

}

Sigma-1 receptor antagonists haloperidol and chlorpromazine modulate the effect of glutoxim on Na+ transport in frog skin. / A. V. Melnitskaya, ; Z. I. Krutetskaya; V. G. Antonov, ; A. D. Nozdrachev.

В: Doklady Biochemistry and Biophysics, Том 484, № 1, 01.05.2019, стр. 63-65.

Результат исследований: Научные публикации в периодических изданияхстатья

TY - JOUR

T1 - Sigma-1 receptor antagonists haloperidol and chlorpromazine modulate the effect of glutoxim on Na+ transport in frog skin

AU - A. V. Melnitskaya, null

AU - Z. I. Krutetskaya, null

AU - V. G. Antonov, null

AU - A. D. Nozdrachev, null

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the firsttime that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazineattenuates the stimulatory effect of glutoxim on the Na+ transport. The results suggest the possibleinvolvement of the sigma-1 receptors in the regulation of Na+ transport in frog skin epithelium by glutoxim.DOI: 10.1134/S1607672919010186

AB - Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the firsttime that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazineattenuates the stimulatory effect of glutoxim on the Na+ transport. The results suggest the possibleinvolvement of the sigma-1 receptors in the regulation of Na+ transport in frog skin epithelium by glutoxim.DOI: 10.1134/S1607672919010186

KW - sigma-1 receptor, immunomodulatory drug glutoxim, neuroleptics, Na+ transport,

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DO - 10.1134/S1607672919010186

M3 - Article

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JF - Doklady Biochemistry and Biophysics

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