Sex differences shape zebrafish performance in a battery of anxiety tests and in response to acute scopolamine treatment

Bruna E. Dos Santos, Ana C. V. V. Giacomini, Leticia Marcon, Konstantin A Demin, Tatyana Strekalova, Murilo S de Abreu, Allan V Kalueff

Результат исследований: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Sex differences influence human and animal behavioral and pharmacological responses. The zebrafish (Danio rerio) is a powerful, popular model system in neuroscience and drug screening. However, the impact of zebrafish sex differences on their behavior and drug responses remains poorly understood. Here, we evaluate baseline anxiety-like behavior in adult male and female zebrafish, and its changes following an acute 30-min exposure to 800-µM scopolamine, a common psychoactive anticholinergic drug. Overall, we report high baseline anxiety-like behavior and more individual variability in locomotion in female zebrafish, as well as distinct, sex-specific (anxiolytic-like in females and anxiogenic-like in males) effects of scopolamine. Collectively, these findings reinforce the growing importance of zebrafish models for studying both individual and sex differences in behavioral and pharmacological responses.

Язык оригиналаанглийский
Номер статьи135993
ЖурналNeuroscience Letters
DOI
СостояниеЭлектронная публикация перед печатью - 2021

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