Semidominant effect of the l(1)ts403 (sbr 10) mutation on sex chromosome nondsjunction in meiosis in Drosophila melanogaster females exposed to heat

E. A. Nikitina, A. V. Komarova, E. V. Golubkova, I. V. Tretyakova, L. A. Mamon

Результат исследований: Научные публикации в периодических изданияхстатья

4 Цитирования (Scopus)

Выдержка

The sbr gene of Drosophila melanogaster belongs to the NXF (nuclear export factor) family responsible for the mRNA transport from nucleus to cytoplasm. We have shown that in the heat-exposed (37°C, 1 h) females, the l(1)ts403 (sbr 10) mutation leads, in particular, to the high-frequency nondisjunction and loss of sex chromosomes in meiosis. For this trait, the incomplete dominance of the sbr 10 mutation is observed. At the same time, the sbr 10 mutation is recessive for many other traits of the heat-exposed flies: reduced viability, low fertility, impaired synthesis of the heat shock proteins, etc. The females heterozygous for the null allele (Df(1)v L4, a deletion eliminating gene srb) do not differ from females homozygous for the wild-type allele in frequency of the heat shock-induced nondisjunction and loss of sex chromosomes in meiosis. Because of this, the sbr 10 mutation can be assigned to the gain-of-function alleles (those gaining the dominance function). Expression of the mutant sbr 10 allele against the background of the wild-type allele suggests that in the heat shock-exposed females, the heat-modified product of this ts allele has an active effect on sex chromosome disjunction in meiosis.

Язык оригиналаанглийский
Страницы (с-по)269-275
Число страниц7
ЖурналRussian Journal of Genetics
Том39
Номер выпуска3
DOI
СостояниеОпубликовано - 1 фев 2003

Отпечаток

Sex Chromosomes
Meiosis
Drosophila melanogaster
Hot Temperature
Alleles
Mutation
Shock
Cell Nucleus Active Transport
Gene Deletion
Heat-Shock Proteins
Gene Frequency
Diptera
Fertility
Cytoplasm
Messenger RNA
Genes

Предметные области Scopus

  • Генетика

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title = "Semidominant effect of the l(1)ts403 (sbr 10) mutation on sex chromosome nondsjunction in meiosis in Drosophila melanogaster females exposed to heat",
abstract = "The sbr gene of Drosophila melanogaster belongs to the NXF (nuclear export factor) family responsible for the mRNA transport from nucleus to cytoplasm. We have shown that in the heat-exposed (37°C, 1 h) females, the l(1)ts403 (sbr 10) mutation leads, in particular, to the high-frequency nondisjunction and loss of sex chromosomes in meiosis. For this trait, the incomplete dominance of the sbr 10 mutation is observed. At the same time, the sbr 10 mutation is recessive for many other traits of the heat-exposed flies: reduced viability, low fertility, impaired synthesis of the heat shock proteins, etc. The females heterozygous for the null allele (Df(1)v L4, a deletion eliminating gene srb) do not differ from females homozygous for the wild-type allele in frequency of the heat shock-induced nondisjunction and loss of sex chromosomes in meiosis. Because of this, the sbr 10 mutation can be assigned to the gain-of-function alleles (those gaining the dominance function). Expression of the mutant sbr 10 allele against the background of the wild-type allele suggests that in the heat shock-exposed females, the heat-modified product of this ts allele has an active effect on sex chromosome disjunction in meiosis.",
author = "Nikitina, {E. A.} and Komarova, {A. V.} and Golubkova, {E. V.} and Tretyakova, {I. V.} and Mamon, {L. A.}",
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Semidominant effect of the l(1)ts403 (sbr 10) mutation on sex chromosome nondsjunction in meiosis in Drosophila melanogaster females exposed to heat. / Nikitina, E. A.; Komarova, A. V.; Golubkova, E. V.; Tretyakova, I. V.; Mamon, L. A.

В: Russian Journal of Genetics, Том 39, № 3, 01.02.2003, стр. 269-275.

Результат исследований: Научные публикации в периодических изданияхстатья

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T1 - Semidominant effect of the l(1)ts403 (sbr 10) mutation on sex chromosome nondsjunction in meiosis in Drosophila melanogaster females exposed to heat

AU - Nikitina, E. A.

AU - Komarova, A. V.

AU - Golubkova, E. V.

AU - Tretyakova, I. V.

AU - Mamon, L. A.

PY - 2003/2/1

Y1 - 2003/2/1

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