Selenium and iodine in diabetes mellitus with a focus on the interplay and speciation of the elements

Nikolay Solovyev, Frank Vanhaecke, Bernhard Michalke

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

Выдержка

Diabetes mellitus is a chronic metabolic disease caused by insulin deficiency (type I) or dysfunction (type II). Diabetes is a threatening public health concern. It is considered as one of the priority non-communicable diseases, due to its high and increasing incidence, the associated healthcare costs, and threatening medical complications. Two trace elements selenium (Se) and iodine (I) were intensively discussed in the context of diabetic pathology and, possibly, etiology. It seems there is a multilayer involvement of these essential nutrients in glucose tolerance, energy metabolism, insulin signaling and resistance, which are mainly related to the antioxidant selenoenzymes and the thyroid hormones. Other factors might be related to (auto)immunity, protection against endoplasmic reticulum stress, and leptin signaling. The aim of the current review is to evaluate the current understanding of the role of selenium and iodine in diabetes with a focus on the biochemical interplay between the elements, their possible role as biomarkers, and their chemical speciation. Possible impacts from novel analytical techniques related to trace element speciation and isotopic analysis are outlined.

Язык оригиналаанглийский
Страницы (с-по)69-80
ЖурналJournal of Trace Elements in Medicine and Biology
Том56
Ранняя дата в режиме онлайн20 июл 2019
DOI
СостояниеОпубликовано - дек 2019

Отпечаток

Trace Elements
Medical problems
Selenium
Iodine
Diabetes Mellitus
Endoplasmic Reticulum Stress
Metabolic Diseases
Leptin
Thyroid Hormones
Chemical speciation
Health Care Costs
Insulin
Energy Metabolism
Insulin Resistance
Immunity
Chronic Disease
Public Health
Antioxidants
Biomarkers
Public health

Предметные области Scopus

  • Биохимия
  • Молекулярная медицина
  • Неорганическая химия

Цитировать

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Selenium and iodine in diabetes mellitus with a focus on the interplay and speciation of the elements. / Solovyev, Nikolay; Vanhaecke, Frank; Michalke, Bernhard.

В: Journal of Trace Elements in Medicine and Biology, Том 56, 12.2019, стр. 69-80.

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

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N2 - Diabetes mellitus is a chronic metabolic disease caused by insulin deficiency (type I) or dysfunction (type II). Diabetes is a threatening public health concern. It is considered as one of the priority non-communicable diseases, due to its high and increasing incidence, the associated healthcare costs, and threatening medical complications. Two trace elements selenium (Se) and iodine (I) were intensively discussed in the context of diabetic pathology and, possibly, etiology. It seems there is a multilayer involvement of these essential nutrients in glucose tolerance, energy metabolism, insulin signaling and resistance, which are mainly related to the antioxidant selenoenzymes and the thyroid hormones. Other factors might be related to (auto)immunity, protection against endoplasmic reticulum stress, and leptin signaling. The aim of the current review is to evaluate the current understanding of the role of selenium and iodine in diabetes with a focus on the biochemical interplay between the elements, their possible role as biomarkers, and their chemical speciation. Possible impacts from novel analytical techniques related to trace element speciation and isotopic analysis are outlined.

AB - Diabetes mellitus is a chronic metabolic disease caused by insulin deficiency (type I) or dysfunction (type II). Diabetes is a threatening public health concern. It is considered as one of the priority non-communicable diseases, due to its high and increasing incidence, the associated healthcare costs, and threatening medical complications. Two trace elements selenium (Se) and iodine (I) were intensively discussed in the context of diabetic pathology and, possibly, etiology. It seems there is a multilayer involvement of these essential nutrients in glucose tolerance, energy metabolism, insulin signaling and resistance, which are mainly related to the antioxidant selenoenzymes and the thyroid hormones. Other factors might be related to (auto)immunity, protection against endoplasmic reticulum stress, and leptin signaling. The aim of the current review is to evaluate the current understanding of the role of selenium and iodine in diabetes with a focus on the biochemical interplay between the elements, their possible role as biomarkers, and their chemical speciation. Possible impacts from novel analytical techniques related to trace element speciation and isotopic analysis are outlined.

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