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RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. / Zaarur, N.; Xu, X.; Lestienne, P.; Meriin, A.B.; McComb, M.; Costello, C.E.; Newnam, G.P.; Ganti, R.; Romanova, N.V.; Shanmugasundaram, M.; Silva, S.T.; Bandeiras, T.M.; Matias, P.M.; Lobachev, K.S.; Lednev, I.K.; Chernoff, Y.O.; Sherman, M.Y.

в: EMBO Journal, Том 34, № 18, 2015, стр. 2363-2382.

Результаты исследований: Научные публикации в периодических изданияхстатья

Harvard

Zaarur, N, Xu, X, Lestienne, P, Meriin, AB, McComb, M, Costello, CE, Newnam, GP, Ganti, R, Romanova, NV, Shanmugasundaram, M, Silva, ST, Bandeiras, TM, Matias, PM, Lobachev, KS, Lednev, IK, Chernoff, YO & Sherman, MY 2015, 'RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils', EMBO Journal, Том. 34, № 18, стр. 2363-2382. https://doi.org/10.15252/embj.201591245

APA

Zaarur, N., Xu, X., Lestienne, P., Meriin, A. B., McComb, M., Costello, C. E., Newnam, G. P., Ganti, R., Romanova, N. V., Shanmugasundaram, M., Silva, S. T., Bandeiras, T. M., Matias, P. M., Lobachev, K. S., Lednev, I. K., Chernoff, Y. O., & Sherman, M. Y. (2015). RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO Journal, 34(18), 2363-2382. https://doi.org/10.15252/embj.201591245

Vancouver

Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE и пр. RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO Journal. 2015;34(18):2363-2382. https://doi.org/10.15252/embj.201591245

Author

Zaarur, N. ; Xu, X. ; Lestienne, P. ; Meriin, A.B. ; McComb, M. ; Costello, C.E. ; Newnam, G.P. ; Ganti, R. ; Romanova, N.V. ; Shanmugasundaram, M. ; Silva, S.T. ; Bandeiras, T.M. ; Matias, P.M. ; Lobachev, K.S. ; Lednev, I.K. ; Chernoff, Y.O. ; Sherman, M.Y. / RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. в: EMBO Journal. 2015 ; Том 34, № 18. стр. 2363-2382.

BibTeX

@article{146a85d41b284df09a0cbf5c06cb1b65,
title = "RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils",
abstract = "The aggresome is an organelle that recruits aggregated proteins for storage and degradation. We performed an siRNA screen for proteins involved in aggresome formation and identified novel mammalian AAA+ protein disaggregases RuvbL1 and RuvbL2. Depletion of RuvbL1 or RuvbL2 suppressed aggresome formation and caused buildup of multiple cytoplasmic aggregates. Similarly, downregulation of RuvbL orthologs in yeast suppressed the formation of an aggresome-like body and enhanced the aggregate toxicity. In contrast, their overproduction enhanced the resistance to proteotoxic stress independently of chaperone Hsp104. Mammalian RuvbL associated with the aggresome, and the aggresome substrate synphilin-1 interacted directly with the RuvbL1 barrel-like structure near the opening of the central channel. Importantly, polypeptides with unfolded structures and amyloid fibrils stimulated the ATPase activity of RuvbL. Finally, disassembly of protein aggregates was promoted by RuvbL. These data indicate that RuvbL complexes se",
keywords = "RuvbL, aggresome, amyloid, disaggregation",
author = "N. Zaarur and X. Xu and P. Lestienne and A.B. Meriin and M. McComb and C.E. Costello and G.P. Newnam and R. Ganti and N.V. Romanova and M. Shanmugasundaram and S.T. Silva and T.M. Bandeiras and P.M. Matias and K.S. Lobachev and I.K. Lednev and Y.O. Chernoff and M.Y. Sherman",
year = "2015",
doi = "10.15252/embj.201591245",
language = "English",
volume = "34",
pages = "2363--2382",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "Wiley-Blackwell",
number = "18",

}

RIS

TY - JOUR

T1 - RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils

AU - Zaarur, N.

AU - Xu, X.

AU - Lestienne, P.

AU - Meriin, A.B.

AU - McComb, M.

AU - Costello, C.E.

AU - Newnam, G.P.

AU - Ganti, R.

AU - Romanova, N.V.

AU - Shanmugasundaram, M.

AU - Silva, S.T.

AU - Bandeiras, T.M.

AU - Matias, P.M.

AU - Lobachev, K.S.

AU - Lednev, I.K.

AU - Chernoff, Y.O.

AU - Sherman, M.Y.

PY - 2015

Y1 - 2015

N2 - The aggresome is an organelle that recruits aggregated proteins for storage and degradation. We performed an siRNA screen for proteins involved in aggresome formation and identified novel mammalian AAA+ protein disaggregases RuvbL1 and RuvbL2. Depletion of RuvbL1 or RuvbL2 suppressed aggresome formation and caused buildup of multiple cytoplasmic aggregates. Similarly, downregulation of RuvbL orthologs in yeast suppressed the formation of an aggresome-like body and enhanced the aggregate toxicity. In contrast, their overproduction enhanced the resistance to proteotoxic stress independently of chaperone Hsp104. Mammalian RuvbL associated with the aggresome, and the aggresome substrate synphilin-1 interacted directly with the RuvbL1 barrel-like structure near the opening of the central channel. Importantly, polypeptides with unfolded structures and amyloid fibrils stimulated the ATPase activity of RuvbL. Finally, disassembly of protein aggregates was promoted by RuvbL. These data indicate that RuvbL complexes se

AB - The aggresome is an organelle that recruits aggregated proteins for storage and degradation. We performed an siRNA screen for proteins involved in aggresome formation and identified novel mammalian AAA+ protein disaggregases RuvbL1 and RuvbL2. Depletion of RuvbL1 or RuvbL2 suppressed aggresome formation and caused buildup of multiple cytoplasmic aggregates. Similarly, downregulation of RuvbL orthologs in yeast suppressed the formation of an aggresome-like body and enhanced the aggregate toxicity. In contrast, their overproduction enhanced the resistance to proteotoxic stress independently of chaperone Hsp104. Mammalian RuvbL associated with the aggresome, and the aggresome substrate synphilin-1 interacted directly with the RuvbL1 barrel-like structure near the opening of the central channel. Importantly, polypeptides with unfolded structures and amyloid fibrils stimulated the ATPase activity of RuvbL. Finally, disassembly of protein aggregates was promoted by RuvbL. These data indicate that RuvbL complexes se

KW - RuvbL

KW - aggresome

KW - amyloid

KW - disaggregation

U2 - 10.15252/embj.201591245

DO - 10.15252/embj.201591245

M3 - Article

VL - 34

SP - 2363

EP - 2382

JO - EMBO Journal

JF - EMBO Journal

SN - 0261-4189

IS - 18

ER -

ID: 3927728