Objective of the study was to conduct a comparative analysis of the frequency of polymorphic alleles (SNP) of the AMPD1 (rs17602729), COL1A1 (rs1800012), and COL5A1 (rs12722) genes in successful figure skaters and children, who had not previously trained or taken part in sports competitions and were still selected for sports sections. Methods and structure of the study. The experiment was run using the materials collected during the implementation of the project of ANO "Stan Chempionom" at Lesgaft National State University of Physical Education, Sport and Health, St. Petersburg. 13 figure skaters of different levels of sports qualification were genotyped in terms of the above-mentioned three polymorphisms: 6 Masters of Sport, 2 Candidate Masters of Sport, 4 I Class athletes, and 1 III Class athlete. The Control Group (CG) was made of 130 children still being selected for sports sections, who had been subjected to the DNA tests under the project of ANO "Stan Chempionom". Results and conclusions. The findings show that in a sport like figure skating, in athletes who regularly train and successfully increase their sports skill and qualification level, the following ancestral alleles predominate in the genotypes: C of the AMPD1 gene (rs17602729), G of the COL1A1 gene (rs1800012), C of the COL5A1 gene (rs12722). This fact suggests that the results obtained in the group of top-class athletes are not random and are supported by the physiological expression of the nature of the above-mentioned genes. Consequently, the findings indicate association of the AMPD1 (rs17602729), COL1A1 (rs1800012), and COL5A1 (rs12722) genes polymorphisms with successful trainings of athletes in figure skating sections. The assumption that the sample results are conditioned by the similarity in athletes’ physiology is interesting, and the authors plan to continue this study by increasing the sample of top-class athletes (HMS and WCMS).