Rol' transaminaz v realizatsii zashchitnogo éffekta L-aspartata pri gipoksii.

I. I. Abu Asali, V. A. Rozanov, A. I. Rozanov

Результат исследований: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Activation of aspartate aminotransferase and alanine aminotransferase of mitochondria introduced to the incubation medium of pyridoxal-5'-phosphate (40 microM) is approximately 2 times higher than that of the corresponding cytoplasmic forms. At hypoxia aspartate aminotransferase activity in mitochondria and postmitochondrial supernatant tends to an increase while that of alanine aminotransferase decreases (above 2 times). The protection from hypoxic damage when using L-aspartate (100 mg/kg subcutaneously 3-5 min before hypoxia) intensifies an adaptive increase of aspartate aminotransferase activity and removes a decrease of alanine aminotransferase activity. Under these conditions stimulating effect of pyridoxal-5'-phosphate on transaminases activity in vitro weakens. A simultaneous administration of vitamin-coenzyme complex (thiamine pyrophosphate, lipoate, sodium 4-phospho-pantothenate, flavin-mononucleotide, nicotinate) intensifies these metabolic shifts and protective action of L-aspartate.

Переведенное названиеThe role of transaminases in realizing the protective effect of L-aspartate in hypoxia
Язык оригиналарусский
Страницы (с-по)77-82
Число страниц6
ЖурналUkrainskii biokhimicheskii zhurnal
Том64
Номер выпуска1
СостояниеОпубликовано - 1 янв 1992

Предметные области Scopus

  • Биохимия

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