Rol' kholesterina v aktivatsii perekisnogo okiseniia lipidov v trombotsitakh.

V. S. Gurevich, L. V. Shatilina, I. G. Kovaleva, B. G. Bershadskiǐ

Результат исследований: Научные публикации в периодических изданияхстатьярецензирование

1 Цитирования (Scopus)

Аннотация

The relationship between the cholesterol (Ch) content and the concentration of lipid peroxidation (LPO) products in activated platelets and the effect of these parameters on the structure-function characteristics of platelet membranes were studied. It was found that esterified Ch activates free radical processes occurring in platelets. Nonesterified Ch does not induce the production of primary products of LPO (dienoic conjugates) but promotes the accumulation of a secondary LPO metabolite, malonic dialdehyde, this reaction being mediated via indirect mechanisms. The higher (in comparison with normal) orderliness and orientation of membranes in platelets reflect the increase in the concentration of dienoic conjugates and nonesterified Ch. The observed differences in the aggregability of platelets are due to the changes in the Ch content as well as to the "rigidity" of blood platelets.

Переведенное названиеThe role of cholesterol in activating lipid peroxidation in platelets
Язык оригиналарусский
Страницы (с-по)267-274
Число страниц8
ЖурналBiokhimiya
Том57
Номер выпуска2
СостояниеОпубликовано - 1 фев 1992

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